Abstract
Transition-metal-catalyzed direct C-H bond functionalizations have attracted considerable attention around the world for almost half a century. In the past decades, great efforts have been made for the development of late transition metals, mainly due to some advantages in terms of the diversity and high efficiency of the catalysts. However, their application was limited on account of their relatively high price, low natural abundance and partly strong toxicity. Cobalt as compared to precious transition metals has shown great potential in the C-H bond functionalizations because of its low cost, unique reactivity profiles and easy availibility in the earth’s crust. This review provides recent advances in direct C-H bond functionalizations mediated by cobalt from C-C and Cheteroatom bond forming reactions.
Keywords: C-C bond formation, C-H bond activation, C-heteroatom bond formation, cobalt catalysts, functionalized reaction.
Graphical Abstract
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Call for Papers in Thematic Issues
31 December, 2024
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
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