Optimisation of [¹¹C]Raclopride Production Using a Synthra GPextent System

Title:Optimisation of [¹¹C]Raclopride Production Using a Synthra GPextent System

Volume: 7 Issue: 2

Author(s): Gary Perkins, Rajeev Sheth, Ivan Greguric and Giancarlo Pascali

Affiliation:

Keywords: 11Carbon, GPextent, optimization, raclopride.

Abstract: The dopamine D₂ receptor radiotracer [¹¹C]Raclopride is used extensively in clinical and preclinical imaging. Currently, a wide range of methods to produce [¹¹C]Raclopride have been developed using traditional vessel reactions as well as cartridge or captive solvent.

This work reports the optimisation of the production of [¹¹C]Raclopride using a Synthra GPextent, comparing various methods. With optimised conditions, we were able to obtain 4±2% (ndc) yield of [¹¹C]Raclopride (100 GBq [¹¹C]CO₂, n = 42) in 25 min. The radiochemical purity was >95% with specific activities of 135±41 MBq/nmol at end of synthesis.

Cite this article as:

Perkins Gary, Sheth Rajeev, Greguric Ivan and Pascali Giancarlo, Optimisation of [¹¹C]Raclopride Production Using a Synthra GPextent System, Current Radiopharmaceuticals 2014; 7 (2) . https://dx.doi.org/10.2174/1874471007666141021111635