摘要
流行病学研究表明饮用绿茶和降低2型糖尿病和其心血管并发症风险之间有重大联系。然而,潜在分子、细胞、生理机制仍不完全清楚。绿茶的促健康作用通常归因于儿茶素没食子酸盐(EGCG),即绿茶中最丰富的多酚。胰岛素抵抗和内皮功能紊乱在2型胰岛素及其心血管并发症中发挥重要作用。代谢胰岛素抵抗归因于骨骼肌和脂肪组织中受损的胰岛素调节的葡萄糖处理和钝化的胰岛素调节的通常与内皮/血管功能障碍有关的肝葡萄糖输出抑制。内皮功能障碍是由其自身引起的,在某种程度上,是通过血管内皮上受损的胰岛素信号导致胰岛素刺激的动脉和调节营养毛细血管的小动脉中NO产生减少引起的。本文中,我们讨论了大量支持在骨骼肌和肝脏中对抗内皮功能障碍和改善代谢胰岛素抵抗的EGCG胰岛素样作用的文献。我们得出结论:EGCG是一种有前景的疗法以对抗心血管并发症联合以胰岛素抵抗和包括肥胖、代谢综合征和2型糖尿病在内的内皮功能障碍间相互关系为特征的代谢疾病。有强大的理由在胰岛素抵抗和糖尿病人群中进行权威的随机安慰剂控制对照干预试验。
关键词: 儿茶素没食子酸盐,内皮功能,绿茶,胰岛素作用,胰岛素敏感性,代谢,肌肉血流量,2型糖尿病。
Current Medicinal Chemistry
Title:Vascular and Metabolic Actions of the Green Tea Polyphenol Epigallocatechin Gallate
Volume: 22 Issue: 1
Author(s): Michelle A. Keske, Huei L.H. Ng, Dino Premilovac, Stephen Rattigan, Jeong-a Kim, Kashif Munir, Peixin Yang and Michael J. Quon
Affiliation:
关键词: 儿茶素没食子酸盐,内皮功能,绿茶,胰岛素作用,胰岛素敏感性,代谢,肌肉血流量,2型糖尿病。
摘要: Epidemiological studies demonstrate robust correlations between green tea consumption and reduced risk of type 2 diabetes and its cardiovascular complications. However, underlying molecular, cellular, and physiological mechanisms remain incompletely understood. Health promoting actions of green tea are often attributed to epigallocatechin gallate (EGCG), the most abundant polyphenol in green tea. Insulin resistance and endothelial dysfunction play key roles in the pathogenesis of type 2 diabetes and its cardiovascular complications. Metabolic insulin resistance results from impaired insulin-mediated glucose disposal in skeletal muscle and adipose tissue, and blunted insulin-mediated suppression of hepatic glucose output that is often associated with endothelial/ vascular dysfunction. This endothelial dysfunction is itself caused, in part, by impaired insulin signaling in vascular endothelium resulting in reduced insulin-stimulated production of NO in arteries, and arterioles that regulate nutritive capillaries. In this review, we discuss the considerable body of literature supporting insulin-mimetic actions of EGCG that oppose endothelial dysfunction and ameliorate metabolic insulin resistance in skeletal muscle and liver. We conclude that EGCG is a promising therapeutic to combat cardiovascular complications associated with the metabolic diseases characterized by reciprocal relationships between insulin resistance and endothelial dysfunction that include obesity, metabolic syndrome and type 2 diabetes. There is a strong rationale for well-powered randomized placebo controlled intervention trials to be carried out in insulin resistant and diabetic populations.
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Michelle A. Keske, Huei L.H. Ng, Dino Premilovac, Stephen Rattigan, Jeong-a Kim, Kashif Munir, Peixin Yang and Quon J. Michael, Vascular and Metabolic Actions of the Green Tea Polyphenol Epigallocatechin Gallate, Current Medicinal Chemistry 2015; 22 (1) . https://dx.doi.org/10.2174/0929867321666141012174553
DOI https://dx.doi.org/10.2174/0929867321666141012174553 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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