摘要
糖尿病是一种人体代谢紊乱,以血液中血糖水平升高为特征,由于遗传易感性和环境因素引起。失衡的血糖控制与进一步衰弱性并发症结合在一起,极大地影响了糖尿病人的生活质量和寿命。嘌呤系统作为一种广泛扩散的信号通路在哺乳动物不同组织的细胞的生理和病理条件下都发挥关键作用。这里我们综述了该嘌呤系统在糖尿病多个方面的重要作用,包括其在生理学和并发症中起的重要作用。我们还讨论了嘌呤途径进行诊断和治疗糖尿病的相关作用。
关键词: β细胞,糖尿病,细胞外ATP ,炎症,胰岛,胰岛免疫,代谢综合征,嘌呤能受体, P2X ,1型糖尿病,2型糖尿病。
Current Medicinal Chemistry
Title:P2X Receptors and Diabetes
Volume: 22 Issue: 7
Author(s): Carmen Fotino, Andrea Vergani, Paolo Fiorina and Antonello Pileggi
Affiliation:
关键词: β细胞,糖尿病,细胞外ATP ,炎症,胰岛,胰岛免疫,代谢综合征,嘌呤能受体, P2X ,1型糖尿病,2型糖尿病。
摘要: Diabetes is a metabolic disorder characterized by elevation of glucose levels in the blood that develops in humans as a result of genetic predisposition and environmental factors. Unbalanced glycemic control has been associated with the development of progressive and debilitating complications that dramatically affect the quality of life and life expectancy of people with diabetes. The purinergic system represents a widely diffused signaling pathway in mammalian cells of different tissues where it plays critical roles in both physiological and pathological conditions. Herein we review the increasing evidence supporting that the purinergic system plays an important role in the multiple facets of diabetes, including its physiopathology and complications. We also discuss the potential relevance of the purinergic pathway for diagnosis and treatment of diabetes.
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Cite this article as:
Carmen Fotino, Andrea Vergani, Paolo Fiorina and Antonello Pileggi , P2X Receptors and Diabetes, Current Medicinal Chemistry 2015; 22 (7) . https://dx.doi.org/10.2174/0929867321666141012173520
DOI https://dx.doi.org/10.2174/0929867321666141012173520 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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