摘要
肿瘤微环境构成了促进肿瘤的生长和恶化的条件,不仅对癌症本身产生作用,还影响其与免疫,内皮细胞和神经细胞的相互作用。细胞外ATP及其受体最近在肿瘤学领域获得越来越多的关。ATP在肿瘤环境中的蓄积通过自发释放,肿瘤坏死或化疗对癌细胞产生营养活性,调节肿瘤之间以及周围组织之间的相互作用。因此, ATP控P2X受体成为在肿瘤的发生发展、侵袭、进展和相关症状中的核心因子。事实上, P2X受体不仅在肿瘤细胞上,而且在免疫浸润和附近的神经元被表达并发挥功能。在这次审查中,我们总结了P2X受体在肿瘤细胞分化、生物能、血管生成、转移和相关的疼痛中的最新研究进展结果,概括了受体激动剂和拮抗剂的潜在抗肿瘤活性。
关键词: 癌症,细胞外ATP , P2X2 , P2X3 , P2X4 , P2X5 , P2X7 ,疼痛。
Current Medicinal Chemistry
Title:Emerging Roles of P2X Receptors in Cancer
Volume: 22 Issue: 7
Author(s): Elena Adinolfi, Marina Capece, Francesca Amoroso, Elena De Marchi and Alessia Franceschini
Affiliation:
关键词: 癌症,细胞外ATP , P2X2 , P2X3 , P2X4 , P2X5 , P2X7 ,疼痛。
摘要: Tumor microenvironment composition strongly conditions cancer growth and progression, acting not only at cancer itself but also modifying its interactions with immune, endothelial and nervous cells. Extracellular ATP and its receptors recently gained increasing attention in the oncological field. ATP accumulates in cancer milieu through spontaneous release, tumor necrosis or chemotherapy exerting a trophic activity on cancer cells, modulating the cross talk among tumor, and surrounding tissues. Accordingly, ATP gated P2X receptors emerged as central players in tumor development, invasion, progression and related symptoms. Indeed, P2X receptors are expressed and are functional not only on tumor cells but also in immune-infiltrate and nearby neurons. In this review, we summarize recent findings on P2X receptors role in tumor cell differentiation, bioenergetics, angiogenesis, metastasis and associated pain, giving an outline of the potential anti-neoplastic activity of receptor agonists and antagonists.
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Cite this article as:
Elena Adinolfi, Marina Capece, Francesca Amoroso, Elena De Marchi and Alessia Franceschini , Emerging Roles of P2X Receptors in Cancer, Current Medicinal Chemistry 2015; 22 (7) . https://dx.doi.org/10.2174/0929867321666141012172913
DOI https://dx.doi.org/10.2174/0929867321666141012172913 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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