摘要
p38分裂原活化蛋白激酶(p38 MAPK, p38)由p38α、 p38β、 p38γ 和 p38δ四个亚基构成。它们对哺乳动物细胞有公认的调节信号传导的作用。p38 MAPK可以诱导多种与神经性疼痛和其它慢性疼痛相关的细胞内反应。因此,p38 MAPK分子特殊特定靶点和其信号通路显示了对可作为止痛的潜在治疗方案。基于对p38 MAPK晶体结构、生物功能和它的信号通路的了解,p38 MAPK抑制剂的化合化学合成已成为可能。天然产物和活性成分也可能是潜在的p38 MAPK抑制剂。为此,我们将评价他们治疗慢性疼痛的潜力。
关键词: 慢性痛,抑制剂,p38 MAPK,信号通路,结构
Current Medicinal Chemistry
Title:p38 MAPK: A Potential Target of Chronic Pain
Volume: 21 Issue: 38
Author(s): X. Lin, M. Wang, J. Zhang and R. Xu
Affiliation:
关键词: 慢性痛,抑制剂,p38 MAPK,信号通路,结构
摘要: p38 mitogen-activated protein kinases (p38 MAPK, p38) consist of 4 subunits: p38α, p38β, p38γ and p38δ. They play a well-recognized role in regulating intracellular signaling transduction in mammalian cells. p38 MAPK induces a variety of intracellular responses associated with neuropathic pain and other chronic pain. Thus, specific targeting p38 MAPK molecule and its signaling pathway represent potential therapeutic strategies for pain management. Based on the understanding of the crystal structure, biological functions and its signaling pathway of p38 MAPK, chemically synthesized p38 MAPK inhibitors have become available. Natural products and biological components may also serve as potential p38 MAPK inhibitors. To this end, we will evaluate their potential for chronic pain management.
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Cite this article as:
Lin X., Wang M., Zhang J. and Xu R., p38 MAPK: A Potential Target of Chronic Pain, Current Medicinal Chemistry 2014; 21 (38) . https://dx.doi.org/10.2174/0929867321666140915143040
DOI https://dx.doi.org/10.2174/0929867321666140915143040 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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