摘要
膳食抗氧化剂在与氧化应激相关的障碍,尤其是神经退行性疾病的治疗应用方面,其对靶器官、组织、细胞的功效、细胞摄取和将抗氧化剂特定的特殊转运仍然是面临的最重要的难题;如而脑靶向性仍是一项未解决的挑战。纳米技术给药投递系统可以解决上面提到的问题,特别是以神经保护活性的膳食抗氧化剂为的靶向投递。纳米技术给药系统可以防止抗氧化剂的降解,并且改善他们的药物理化性质及他们的生物利用度。 本文突出强调了纳米医学在改善膳食抗氧化剂方面的影响,如 氧化应激抗氧化剂 , 尤其是通过利用使用药物投递系统的抗氧化剂;,及以及通常常规的以给药为目的纳米材料类型。 根据这些材料,我们推断出抗氧化剂(膳食)和纳米技术联用的研究,也就是神经退行性疾病的治疗方法,仍然处于初期阶段。因此,大更广泛的研究领域仍需研究,希望在可预见的时期,能够研究出新的、有效的神经保护治疗剂。
关键词: 膳食抗氧化剂,纳米载体,神经退行性疾病,氧化应激相关疾病
Current Medicinal Chemistry
Title:Nanotechnology and Antioxidant Therapy: An Emerging Approach for Neurodegenerative Diseases
Volume: 21 Issue: 38
Author(s): Carlos Fernandes, Catarina Oliveira, Sofia Benfeito, Pedro Soares, Jorge Garrido and Fernanda Borges
Affiliation:
关键词: 膳食抗氧化剂,纳米载体,神经退行性疾病,氧化应激相关疾病
摘要: The efficacy, cellular uptake and specific transport of dietary antioxidants to target organs, tissues and cells remains the most important setback for their application in the treatment of oxidative-stress related disorders and in particular in neurodegenerative diseases, as brain targeting remains a still unsolved challenge. Nanotechnology based delivery systems can be a solution for the above mentioned problems, specifically in the case of targeting dietary antioxidants with neuroprotective activity. Nanotechnology-based delivery systems can protect antioxidants from degradation, improve their physicochemical drug-like properties and in turn their bioavailability.
The impact of nanomedicine in the improvement of the performance of dietary antioxidants, as protective agents in oxidative- stress events, specifically through the use of drug delivery systems, is highlighted in this review as well as the type of nanomaterials regularly used for drug delivery purposes.
From the data one can conclude that the research combining (dietary) antioxidants and nanotechnology, namely as a therapeutic solution for neurodegenerative diseases, is still in a very early stage. So, a huge research area remains to be explored that hopefully will yield new and effective neuroprotective therapeutic agents in a foreseeable future.
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Cite this article as:
Fernandes Carlos, Oliveira Catarina, Benfeito Sofia, Soares Pedro, Garrido Jorge and Borges Fernanda, Nanotechnology and Antioxidant Therapy: An Emerging Approach for Neurodegenerative Diseases, Current Medicinal Chemistry 2014; 21 (38) . https://dx.doi.org/10.2174/0929867321666140915141836
DOI https://dx.doi.org/10.2174/0929867321666140915141836 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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