Abstract
The increasing prevalence of persistent biofilm infections, such as wound infections, chronic lung infections or medical device- related infections, which usually tolerate conventional antibiotic treatment, calls for the development of new therapeutic strategies. To date, antimicrobial peptides (AMPs) are considered as promising agents in the fight against multidrug-resistant bacterial biofilm infections, since many of them have been shown to prevent biofilm formation or even kill preexisting, mature biofilms of several Grampositive and Gram-negative bacteria in addition to their bactericidal actions to planktonic cells. In this mini-review, we summarize in vitro and in vivo antibiofilm properties of natural and synthetic cationic AMPs against clinically relevant bacterial pathogens. Furthermore, the benefits and challenges in the use of AMPs for the medical treatment of bacterial biofilm infections are discussed.
Keywords: Antimicrobial peptide, cationic peptides, biofilm infection, host defense peptide, multidrug-resistant bacteria, chronic infection, antibiofilm.
Current Pharmaceutical Design
Title:Potential Application of Antimicrobial Peptides in the Treatment of Bacterial Biofilm Infections
Volume: 21 Issue: 1
Author(s): Nikola Strempel, Janine Strehmel and Joerg Overhage
Affiliation:
Keywords: Antimicrobial peptide, cationic peptides, biofilm infection, host defense peptide, multidrug-resistant bacteria, chronic infection, antibiofilm.
Abstract: The increasing prevalence of persistent biofilm infections, such as wound infections, chronic lung infections or medical device- related infections, which usually tolerate conventional antibiotic treatment, calls for the development of new therapeutic strategies. To date, antimicrobial peptides (AMPs) are considered as promising agents in the fight against multidrug-resistant bacterial biofilm infections, since many of them have been shown to prevent biofilm formation or even kill preexisting, mature biofilms of several Grampositive and Gram-negative bacteria in addition to their bactericidal actions to planktonic cells. In this mini-review, we summarize in vitro and in vivo antibiofilm properties of natural and synthetic cationic AMPs against clinically relevant bacterial pathogens. Furthermore, the benefits and challenges in the use of AMPs for the medical treatment of bacterial biofilm infections are discussed.
Export Options
About this article
Cite this article as:
Strempel Nikola, Strehmel Janine and Overhage Joerg, Potential Application of Antimicrobial Peptides in the Treatment of Bacterial Biofilm Infections, Current Pharmaceutical Design 2015; 21 (1) . https://dx.doi.org/10.2174/1381612820666140905124312
DOI https://dx.doi.org/10.2174/1381612820666140905124312 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Polyproline and Triple Helix Motifs in Host-Pathogen Recognition
Current Protein & Peptide Science Disseminated TB in an Immunocompetent Patient: A Case Report
Infectious Disorders - Drug Targets Small Molecule Inhibitors Limit Endothelial Cell Invasion by Staphylococcus aureus
Current Pharmaceutical Biotechnology Systemic Inflammatory Response as a Risk and Prognosis Factor in Ventilator-Associated Pneumonia
Current Respiratory Medicine Reviews Activation of Macrophages: Establishing a Role for Polysaccharides in Drug Delivery Strategies Envisaging Antibacterial Therapy
Current Pharmaceutical Design Ceftriaxone-Vancomycin Drug Toxicity Reduction by VRP 1020 in Mus musculus Mice
Current Clinical Pharmacology Role of Natural Product in Modulation of Drug Transporters and New Delhi Metallo-β Lactamases
Current Topics in Medicinal Chemistry Indications of Anti-Inflammatory Drugs in Cardiac Diseases
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry Antimicrobial Development in the Era of Emerging Resistance
Mini-Reviews in Medicinal Chemistry Rashes, Sniffles, and Stroke: A Role for Infection in Ischemic Stroke of Childhood
Infectious Disorders - Drug Targets First Report on the Characteristics of Methicillin-Resistant <i>Staphylococcus Capitis</i> Isolates and an NRCS-A-clone Related Isolate Obtained from Iranian Children
Infectious Disorders - Drug Targets The Rise of Carbapenem-Resistant Acinetobacter baumannii
Current Pharmaceutical Design Proteomics of Biofilm Bacteria
Current Proteomics COVID-19: How Nuclear Medicine Can Provide A Differential Diagnosis In A Very Dubious Case
Coronaviruses Ischemic Strokes in Congenital Bleeding Disorders: Comparison with Myocardial Infarction and other Acute Coronary Syndromes
Cardiovascular & Hematological Disorders-Drug Targets Plasma Pharmacokinetics of Antimicrobial Agents in Critically Ill Patients
Current Clinical Pharmacology The Family of Serratia Type Pore Forming Toxins
Current Protein & Peptide Science Exploring the Biology and Structural Architecture of Sortase Role on Biofilm Formation in Gram Positive Pathogens
Current Topics in Medicinal Chemistry Cardiovascular Disease in Antiphospholipid Syndrome
Current Vascular Pharmacology New Developments in Antimicrobial Use in Sepsis
Current Pharmaceutical Design