摘要
循环肿瘤细胞(CTCs)作为癌症转移的生物标志物,循环肿瘤细胞(CTCs)激发起了研究人员的浓厚兴趣,但直到最近才建立起了检测CTC的可靠方法。CTCs可以被看作认为是取自血液的液体切片,它们可以用于病理学和分子学试验。CTCs可以较理想地取代转移性组织切片并预测肿瘤复发和监测治疗效果。CTC可用于指导对癌症治疗进行操控,并用作为药物靶标。出于这个原因,本文在此论述了该技术的潜力和CTCs检测的现有方法的局限性。CTC的临床应用包括预测癌症预后,选择并监测治疗方案,作为药物靶标。CTCs分子的表达剖析方式有利于预后与癌症治疗方案的选择。
关键词: 循环肿瘤细胞,药物靶标,富集和检测,免疫治疗。
Current Drug Targets
Title:Circulating Tumor Cells (CTCs) as a Liquid Biopsy Material and Drug Target
Volume: 15 Issue: 10
Author(s): Liang-Liang Cai, Hui-Ming Ye, Li-Mou Zheng, Run-Sheng Ruan and Chi-Meng Tzeng
Affiliation:
关键词: 循环肿瘤细胞,药物靶标,富集和检测,免疫治疗。
摘要: Circulating tumor cells (CTCs) have attracted interest as biomarkers of cancer metastases but only recently has a reliable method of CTC detection been developed. CTCs can be thought of as a liquid biopsy from the blood, and they can be used in pathological and molecular assays. CTCs may ideally replace metastatic tissue biopsies in the prediction and monitoring of therapeutic responses and tumor recurrence. CTCs can be used to guide therapeutic cancer management and serve as drug targets. For this reason, the potential of this technology and the limitations of currently available methods of CTC detection are addressed here. The clinical applications of CTCs include the prediction of cancer prognosis; selection and monitoring of therapeutic regimens; and drug target applications. The manner in which CTC molecular profiling can facilitate prognosis and the selection of cancer therapies.
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Cite this article as:
Cai Liang-Liang, Ye Hui-Ming, Zheng Li-Mou, Ruan Run-Sheng and Tzeng Chi-Meng, Circulating Tumor Cells (CTCs) as a Liquid Biopsy Material and Drug Target, Current Drug Targets 2014; 15 (10) . https://dx.doi.org/10.2174/1389450115666140902125150
DOI https://dx.doi.org/10.2174/1389450115666140902125150 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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