摘要
Spalt( SAL )家族是一类进化上保守的基因,最初在果蝇确定为胚胎发育需要的同源异型基因。在脊椎动物中,sal-like 4(SALL4)特别多的表达在胚胎和成年干细胞/干细胞样细胞。SALL4是一个重要的调节器有助于生物发育细胞的干性和肿瘤生长,因此,SALL4已经成为基因治疗的靶标。此外,许多影响SALL4基因的突变被发现在临床上与一系列的先天性异常关联,如杜安/ 杜安相关综合征,心室中隔缺损,卵巢功能早衰。本综述描述了SALL4关键功能的潜在机制及其作为基因治疗的靶标。最后,我总结和讨论了Sall4的应用及其诊断和治疗人类疾病功能的进展。
关键词: 癌症,杜安综合症,胚胎发育,造血作用,Sall4,干细胞
Current Gene Therapy
Title:SALL4: Engine of Cell Stemness
Volume: 14 Issue: 5
Author(s): Jianhua Xiong
Affiliation:
关键词: 癌症,杜安综合症,胚胎发育,造血作用,Sall4,干细胞
摘要: The spalt (sal) family is a class of evolutionarily conserved genes originally identified in Drosophila as homeotic genes required for embryonic development. In vertebrates, the expression of sal-like 4 (SALL4) is specifically enriched in both embryonic and adult stem/stem-like cells. SALL4 is a master regulator that contributes to cell stemness in biological development and tumor growth. Thus, Sall4 has emerged as a target for gene therapy. In addition, numerous mutations affecting the Sall4 gene have been discovered and clinically linked to a series of congenital abnormalities, such as Duane/Duane-related syndromes, ventricular septal defect and premature ovarian failure. This review delineates the underlying mechanisms of key functions of SALL4 and its use as a target for gene therapy. Finally, I summarize and discuss advances made on the application of Sall4 and its functions in diagnostics and treatments for human diseases.
Export Options
About this article
Cite this article as:
Xiong Jianhua, SALL4: Engine of Cell Stemness, Current Gene Therapy 2014; 14 (5) . https://dx.doi.org/10.2174/1566523214666140825125138
DOI https://dx.doi.org/10.2174/1566523214666140825125138 |
Print ISSN 1566-5232 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5631 |
Call for Papers in Thematic Issues
Programmed Cell Death Genes in Oncology: Pioneering Therapeutic and Diagnostic Frontiers (BMS-CGT-2024-HT-45)
Programmed Cell Death (PCD) is recognized as a pivotal biological mechanism with far-reaching effects in the realm of cancer therapy. This complex process encompasses a variety of cell death modalities, including apoptosis, autophagic cell death, pyroptosis, and ferroptosis, each of which contributes to the intricate landscape of cancer development and ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
PET Imaging to Monitor Cancer Therapy
Current Pharmaceutical Biotechnology Current Status and Future Perspectives of Chemoprevention in Head and Neck Cancer
Current Cancer Drug Targets Synthesis, Cytotoxicity Evaluation and Molecular Docking of Fluorine Containing Hexahydroquinoline-3-Carbonitrile Derivatives
Current Drug Discovery Technologies Signal Transduction Inhibitors in the Treatment of Breast Cancer
Current Medicinal Chemistry - Anti-Cancer Agents PI3K/AKT/mTOR Inhibitors In Ovarian Cancer
Current Medicinal Chemistry Statins and Alkylphospholipids as New Anticancer Agents Targeting Lipid Metabolism
Anti-Cancer Agents in Medicinal Chemistry Aging and Systemic Lupus Erythematosus - Immunosenescence and Beyond
Current Aging Science Fibroblast Growth Factors/Fibroblast Growth Factor Receptors as Targets for the Development of Anti-Angiogenesis Strategies
Current Pharmaceutical Design Netrin and DCC: Axon Guidance Regulators at the Intersection of Nervous System Development and Cancer
Current Drug Targets Innovative Roles for Surgical Robotics in Reproductive Surgery
Current Women`s Health Reviews PDGF/PDGFR Signaling and Targeting in Cancer Growth and Progression: Focus on Tumor Microenvironment and Cancer-associated Fibroblasts
Current Pharmaceutical Design Prophylaxis of Cancer
Current Cancer Therapy Reviews Receptor Tyrosine Kinases as Therapeutic Targets in Malignant Glioma
Reviews on Recent Clinical Trials Pharmacology of Rhein and Advancement in the Synthesis of Its Derivatives
Current Traditional Medicine The CCL2/CCR2 Axis in the Pathogenesis of HIV-1 Infection: A New Cellular Target for Therapy?
Current Drug Targets Bone Modulating Bioactive Natural Compounds: Review
Current Bioactive Compounds (Iso)Flav(an)ones, Chalcones, Catechins, and Theaflavins as Anticarcinogens: Mechanisms, Anti-Multidrug Resistance and QSAR Studies
Current Medicinal Chemistry Metformin as a Radiation Modifier; Implications to Normal Tissue Protection and Tumor Sensitization
Current Clinical Pharmacology Angiotensin-I Converting Enzyme Inhibitors as Potential Anti-Angiogenic Agents for Cancer Therapy
Current Cancer Drug Targets The Discovery of HPV and its Clinical Implications
Current Cancer Therapy Reviews