NEDD4: A Promising Target for Cancer Therapy

Title:NEDD4: A Promising Target for Cancer Therapy

Volume: 14 Issue: 6

Author(s): Xiantao Ye, Lixia Wang, Bingxue Shang, Zhiwei Wang and Wenyi Wei

Affiliation:

Keywords: Cancer, E3 ligase, NEDD4, oncogene, target, therapy, ubiquitination.

Abstract: The Neuronally expressed developmentally downregulated 4 (NEDD4), functioning largely as an E3 ubiquitin ligase, has been demonstrated to play a critical role in the development and progression of human cancers. In this review, to understand the regulatory mechanism(s) of NEDD4 as well as the signaling pathways controlled by NEDD4, we briefly describe the NEDD4 upstream regulators and its downstream ubiquitin substrates. Moreover, we further discuss its oncogenic roles in human malignancies. Therefore, targeting NEDD4 could be a potential therapeutic strategy for treatment of human cancers.

Cite this article as:

Ye Xiantao, Wang Lixia, Shang Bingxue, Wang Zhiwei and Wei Wenyi, NEDD4: A Promising Target for Cancer Therapy, Current Cancer Drug Targets 2014; 14 (6) . https://dx.doi.org/10.2174/1568009614666140725092430