摘要
一些代谢疾病呈现出高心血管死亡率,这是由于内皮功能障碍所引起的后果。在上世纪的最后几年,关于内皮细胞的说法开始明朗起来,过去其被认为在最终的分泌活动中表现为分泌惰性,然而内皮细胞却在调节不同方面的血管功能(内皮功能)上发挥关键作用。明确证实了内皮细胞充当着真正的活性器官,拥有内分泌、旁分泌和自分泌的调制活性,及通过这些活性则能够调节血管稳态。这篇综述将调查研究一些代谢疾病和内皮功能障碍之间的关系,尤其是在内皮代谢疾病影响下的潜在机制。此外,还将考虑到在这些情况下N-乙酰半胱氨酸的可能的治疗作用。
关键词: 抗氧化剂,环磷酸鸟苷,糖尿病,代谢综合征,一氧化氮,N-乙酰半胱氨酸,氧化,氧化应激,多囊卵巢综合征,硫醇类,肥胖症
Current Medicinal Chemistry
Title:Endothelial Dysfunction in Metabolic Diseases: Role of Oxidation and Possible Therapeutic Employment of N-acetylcysteine
Volume: 21 Issue: 32
Author(s): A. Masha and V. Martina
Affiliation:
关键词: 抗氧化剂,环磷酸鸟苷,糖尿病,代谢综合征,一氧化氮,N-乙酰半胱氨酸,氧化,氧化应激,多囊卵巢综合征,硫醇类,肥胖症
摘要: Several metabolic diseases present a high cardiovascular mortality due to endothelial dysfunction consequences. In the last years of the past century, it has come to light that the endothelial cells, previously considered as inert in what regards an eventual secretion activity, play a pivotal role in regulating different aspects of the vascular function (endothelial function). It was clearly demonstrated that the endothelium acts as a real active organ, owning endocrine, paracrine and autocrine modulation activities by means of which it is able to regulate the vascular homeostasis. The present review will investigate the relationship between some metabolic diseases and the endothelial dysfunction and in particular the mechanisms underlying the effects of metabolic pathologies on the endothelium. Furthermore, it will consider the possible therapeutic employment of the N-acetilcysteine in such conditions.
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Cite this article as:
Masha A. and Martina V., Endothelial Dysfunction in Metabolic Diseases: Role of Oxidation and Possible Therapeutic Employment of N-acetylcysteine, Current Medicinal Chemistry 2014; 21 (32) . https://dx.doi.org/10.2174/0929867321666140706132900
DOI https://dx.doi.org/10.2174/0929867321666140706132900 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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