Synthesis, Anticonvulsant and Antimicrobial Activities of Some New [1-(2-Naphthyl)-2-(pyrazol-1-yl)ethanone]oxime Ethers

Title:Synthesis, Anticonvulsant and Antimicrobial Activities of Some New [1-(2-Naphthyl)-2-(pyrazol-1-yl)ethanone]oxime Ethers

Volume: 11 Issue: 1

Author(s): Zeynep Ozdemir, Arzu Karakurt, Unsal Calis, Selami Gunal, Samil Isik, Z. Sibel Sahin and Sevim Dalkara

Affiliation:

Keywords: (Arylalkyl)azole, pyrazole, oxime ether, anticonvulsant, antimicrobial, X-ray crystallography.

Abstract: In this study, 12 new oxime ether derivatives, which were expected to show anticonvulsant and antimicrobial activities, were synthesized. Oxime ether derivatives were synthesized by the reaction of various alkyl halides with 1-(2- naphthyl)-2-(pyrazol-1-yl)ethanone oxime. Anticonvulsant activity of the compounds was determined by maximal electroshock (MES) and subcutaneous metrazol (ScM) seizure tests, while neurological disorders were evaluated using rotorod toxicity test according to the ASP of NIH. Compound 1, 6 and 7 showed anticonvulsant activity at 300 mg/kg dose at 4 h, but compounds 1 and 7 showed toxicity at 300 mg/kg dose at half an hour. Antimicrobial activities of the compounds were also determined using agar microdilution method. Compound 1 and 5 were found to have the highest antifungal activity among the other compounds.

Cite this article as:

Ozdemir Zeynep, Karakurt Arzu, Calis Unsal, Gunal Selami, Isik Samil, Sahin Sibel Z. and Dalkara Sevim, Synthesis, Anticonvulsant and Antimicrobial Activities of Some New [1-(2-Naphthyl)-2-(pyrazol-1-yl)ethanone]oxime Ethers, Medicinal Chemistry 2015; 11 (1) . https://dx.doi.org/10.2174/1573406410666140428150358