Enantioselective Synthesis in Carbohydrate-Based Drug Discovery: Imino Sugars, Alkaloids and Macrolide Antibiotics

Nuno   M.   Xavier; Amélia   P.   Rauter

doi:10.2174/1568026614666140423103848

Abstract

This review is dedicated to enantioselective methods for the generation of carbohydrate-based lead compounds for drug research. Selected examples encompassing imino sugars, bicyclic imino sugar-type alkaloids such as castanospermine, swainsonine, or alexine, as well as macrolide glycosides are covered and discussed.

Keywords: Alkaloids, carbohydrates, enantioselective synthesis, imino sugars, macrolide glycosides.

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Current Topics in Medicinal Chemistry

Title:Enantioselective Synthesis in Carbohydrate-Based Drug Discovery: Imino Sugars, Alkaloids and Macrolide Antibiotics

Volume: 14 Issue: 10

Author(s): Nuno M. Xavier and Amélia P. Rauter

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Keywords: Alkaloids, carbohydrates, enantioselective synthesis, imino sugars, macrolide glycosides.

Abstract: This review is dedicated to enantioselective methods for the generation of carbohydrate-based lead compounds for drug research. Selected examples encompassing imino sugars, bicyclic imino sugar-type alkaloids such as castanospermine, swainsonine, or alexine, as well as macrolide glycosides are covered and discussed.

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Xavier M. Nuno and Rauter P. Amélia, Enantioselective Synthesis in Carbohydrate-Based Drug Discovery: Imino Sugars, Alkaloids and Macrolide Antibiotics, Current Topics in Medicinal Chemistry 2014; 14 (10) . https://dx.doi.org/10.2174/1568026614666140423103848

DOI https://dx.doi.org/10.2174/1568026614666140423103848	Print ISSN 1568-0266
Publisher Name Bentham Science Publisher	Online ISSN 1873-4294