Conformational Preferences of Chiral Acyclic Homooligomeric β2,2-Peptides

Fernando      Rodriguez; Francisco      Corzana; Alberto      Avenoza; Jesus   Hector   Busto; Jesus   Manuel   Peregrina; Maria   del   Mar Zurbano

doi:10.2174/1568026614666140423101226

Abstract

α-Methylisoserine, a chiral acyclic quaternary β-amino acid, has been used to mimic secondary structures, when it is incorporated in a homogeneous β^2,2-dipeptide. In particular, the observed folded conformations in aqueous solution can be regarded as mimics of β-turn.

Keywords: β-Peptides, conformational analysis, molecular dynamics, nuclear magnetic resonance.

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Current Topics in Medicinal Chemistry

Title:Conformational Preferences of Chiral Acyclic Homooligomeric β^2,2-Peptides

Volume: 14 Issue: 10

Author(s): Fernando Rodriguez, Francisco Corzana, Alberto Avenoza, Jesus Hector Busto, Jesus Manuel Peregrina and Maria del Mar Zurbano

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Keywords: β-Peptides, conformational analysis, molecular dynamics, nuclear magnetic resonance.

Abstract: α-Methylisoserine, a chiral acyclic quaternary β-amino acid, has been used to mimic secondary structures, when it is incorporated in a homogeneous β^2,2-dipeptide. In particular, the observed folded conformations in aqueous solution can be regarded as mimics of β-turn.

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Rodriguez Fernando, Corzana Francisco, Avenoza Alberto, Busto Hector Jesus, Peregrina Manuel Jesus and Mar Zurbano del Maria, Conformational Preferences of Chiral Acyclic Homooligomeric β^2,2-Peptides, Current Topics in Medicinal Chemistry 2014; 14 (10) . https://dx.doi.org/10.2174/1568026614666140423101226

DOI https://dx.doi.org/10.2174/1568026614666140423101226	Print ISSN 1568-0266
Publisher Name Bentham Science Publisher	Online ISSN 1873-4294