Diagnostic und Therapeutic Value of Cell-free Circulating DNA as a Non-invasive Biomarker in Patients with Prostate Cancer

Title:Diagnostic und Therapeutic Value of Cell-free Circulating DNA as a Non-invasive Biomarker in Patients with Prostate Cancer

Volume: 9 Issue: 4

Author(s): Stefan Latz, Stefan C. Muller and Jorg Ellinger

Affiliation:

Keywords: Prostate cancer, DNA fragmentation, cell-free DNA, DNA methylation, allelic imbalance.

Abstract: The presence of small amounts of circulating DNA in plasma was demonstrated 60 years ago. Since then, cellfree DNA has been tested for quantity, fragmentation pattern and tumor-specific sequences in patients with various malignancies. The introduction of improved detection methods showed that all these alterations are regularly detectable in many cancer patients and the investigation of cell-free DNA may provide useful diagnostic and prognostic information. Herein, we review the recent findings on cell-free DNA alterations in patients with prostate cancer and discuss its diagnostic and prognostic potential.

Cite this article as:

Latz Stefan, Muller Stefan C. and Ellinger Jorg, Diagnostic und Therapeutic Value of Cell-free Circulating DNA as a Non-invasive Biomarker in Patients with Prostate Cancer, Current Cancer Therapy Reviews 2013; 9 (4) . https://dx.doi.org/10.2174/157339470904140418094329