Abstract
Abnormalities in myocardial energy metabolism occur in association with progression to congestive heart failure. Conceivably, alterations in cardiac energy metabolism may initiate trophic responses or remodeling noted in myocardium during various disease processes. This review will explore the relationship between myocardial remodeling, contractile dysfunction, and myocardial bioenergetics. Attention will be given to data obtained from studies performed using intact animal models, which emulate congestive heart failure in humans. These data will be considered in relation to studies performed in vitro or in transgenic models. Focus will also be directed towards mechanisms of mitochondrial oxidative phosphorylation regulation (OXPHOS) and high energy phosphate transport.
Keywords: adenine nucleotide translocator, creatine kinase, adenylate kinase, phosphocreatine
Current Cardiology Reviews
Title: Myocardial Energy Transport and Heart Failure
Volume: 1 Issue: 1
Author(s): Michael A. Portman and Jianyi Zhang
Affiliation:
Keywords: adenine nucleotide translocator, creatine kinase, adenylate kinase, phosphocreatine
Abstract: Abnormalities in myocardial energy metabolism occur in association with progression to congestive heart failure. Conceivably, alterations in cardiac energy metabolism may initiate trophic responses or remodeling noted in myocardium during various disease processes. This review will explore the relationship between myocardial remodeling, contractile dysfunction, and myocardial bioenergetics. Attention will be given to data obtained from studies performed using intact animal models, which emulate congestive heart failure in humans. These data will be considered in relation to studies performed in vitro or in transgenic models. Focus will also be directed towards mechanisms of mitochondrial oxidative phosphorylation regulation (OXPHOS) and high energy phosphate transport.
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Cite this article as:
Portman A. Michael and Zhang Jianyi, Myocardial Energy Transport and Heart Failure, Current Cardiology Reviews 2005; 1 (1) . https://dx.doi.org/10.2174/1573403052952347
DOI https://dx.doi.org/10.2174/1573403052952347 |
Print ISSN 1573-403X |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6557 |
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