Abstract
Recent developments in the microwave-assisted synthesis of carbo- and heterocyclicsystems are reviewed with the focus on diversity-oriented cycloaddition reactions. Ineed, these reactions represent one of the most important endeavors in chemistry and are of considerable interest in the synthesis of carbo-and heterocyclic compounds from simple unsaturated systems, and allow the creation of more than two bonds in one step. This review summarizes recent literature (2006-2013) on advances regarding [3+2], [4+2] and [2+2] cycloadditions including their miscellaneous version. Advantages of microwave dielectric heating are highlighted by comparison with conventional thermal conditions. In particular, we describe here the microwave effect, reaction media including solvent-free transformations and more ecological processes in the context of green and environmentally benign chemistry.
Keywords: [2+2] cycloaddition, 1, 3-dipolar cycloaddition, carbocycles, diels-alder, green catalysis, green chemistry, heterocycles, microwave synthesis.
Graphical Abstract
Current Organic Chemistry
Title:Microwave-assisted Cycloaddition Reactions in Carbo- and Heterocyclic Chemistry
Volume: 18 Issue: 16
Author(s): Aziza Saber, Hamid Marzag, Rachid Benhida and Khalid Bougrin
Affiliation:
Keywords: [2+2] cycloaddition, 1, 3-dipolar cycloaddition, carbocycles, diels-alder, green catalysis, green chemistry, heterocycles, microwave synthesis.
Abstract: Recent developments in the microwave-assisted synthesis of carbo- and heterocyclicsystems are reviewed with the focus on diversity-oriented cycloaddition reactions. Ineed, these reactions represent one of the most important endeavors in chemistry and are of considerable interest in the synthesis of carbo-and heterocyclic compounds from simple unsaturated systems, and allow the creation of more than two bonds in one step. This review summarizes recent literature (2006-2013) on advances regarding [3+2], [4+2] and [2+2] cycloadditions including their miscellaneous version. Advantages of microwave dielectric heating are highlighted by comparison with conventional thermal conditions. In particular, we describe here the microwave effect, reaction media including solvent-free transformations and more ecological processes in the context of green and environmentally benign chemistry.
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Cite this article as:
Saber Aziza, Marzag Hamid, Benhida Rachid and Bougrin Khalid, Microwave-assisted Cycloaddition Reactions in Carbo- and Heterocyclic Chemistry, Current Organic Chemistry 2014; 18 (16) . https://dx.doi.org/10.2174/1385272819666140407213427
DOI https://dx.doi.org/10.2174/1385272819666140407213427 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
Chemistry and Biology of Carbohydrates
Carbohydrates are one of the most abundant natural products and are considered to be extremely important biomolecules for their ever-increasing impact on chemistry and biology. Their role in several important biological processes, notably energy storage, transport, modulation of protein function, intercellular adhesion, malignant transformation, signal transduction, viral, and bacterial cell ...read more
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