Ubiquitin Carboxyl Hydrolase L1 Significance for Human Diseases

Title:Ubiquitin Carboxyl Hydrolase L1 Significance for Human Diseases

Volume: 21 Issue: 7

Author(s): Dang Ngoc Anh Suong, Dang Thi Phuong Thao, Yamaguchi Masamitsu and Tran Linh Thuoc

Affiliation:

Keywords: Cancer, diabetes type-2, Parkinson’s disease, ubiquitination, UCH-L1, Ubiquitin proteasome system.

Abstract: Ubiquitin carboxyl hydrolase L1 (UCH-L1) is an abundant multifunctional neuron protein. It plays an important role in maintaining the ubiquitin proteasome system (UPS), vital for recognizing and degrading dysfunctional proteins in organisms. In recent decades, UCH-L1 has been implicated in the pathogenesis of many diseases, including neurodegenerative disorders, cancer and diabetes. However, the mechanisms of UCH-L1 involvement have yet to be revealed in detail. Since UCH-L1 contributes many different functions to cell metabolism, its role and regulation might be more complex than previously thought and it has become a research target in many laboratories. In this review, we summarize recent findings related to the actions of UCH-L1 in several human diseases.

Cite this article as:

Suong Ngoc Anh Dang, Thao Thi Phuong Dang, Masamitsu Yamaguchi and Thuoc Linh Tran, Ubiquitin Carboxyl Hydrolase L1 Significance for Human Diseases, Protein & Peptide Letters 2014; 21 (7) . https://dx.doi.org/10.2174/0929866521666140403125959