Peptides-Staple Method Development and Its Application in Cancer Therapy

Title:Peptides-Staple Method Development and Its Application in Cancer Therapy

Volume: 21 Issue: 21

Author(s): Q.Z. Zhang, Y. Tian, Y.Z. Lao and Z.-G. Li

Affiliation:

Keywords: Cancer therapy, protein-protein interaction, stapled peptide, α-helix.

Abstract: α-Helixes are important structural motifs of protein three dimension structures and are largely involved in protein- protein interactions. This review covers the recent advances of the peptide stabilizing methodologies and introduces their applications in cancer research.

Cite this article as:

Zhang Q.Z., Tian Y., Lao Y.Z. and Li Z.-G., Peptides-Staple Method Development and Its Application in Cancer Therapy, Current Medicinal Chemistry 2014; 21 (21) . https://dx.doi.org/10.2174/0929867321666140205130835