Abstract
The purpose of this mini-review is to summarize and highlight the different advances in our understanding of the antimicrobial and antiangiogenic activity of squalamine, a cationic steroid isolated in 1993 from the dogfish shark Squalus Acanthias. Indeed, squalamine has shown to be useful for the treatment of important diseases such as cancers (lung, ovarian, brain and others), age-related macular degeneration (AMD) and the control of body weight in man. All these results led to a question: could we consider squalamine as a polyvalent drug of the future?
Keywords: squalamine, aminosterol, cancer, age-related macular degeneration (amd), appetite suppression, weight reduction
Current Cancer Drug Targets
Title: Squalamine: A Polyvalent Drug of the Future?
Volume: 5 Issue: 4
Author(s): Jean Michel Brunel, Chanaz Salmi, Celine Loncle, Nicolas Vidal and Yves Letourneux
Affiliation:
Keywords: squalamine, aminosterol, cancer, age-related macular degeneration (amd), appetite suppression, weight reduction
Abstract: The purpose of this mini-review is to summarize and highlight the different advances in our understanding of the antimicrobial and antiangiogenic activity of squalamine, a cationic steroid isolated in 1993 from the dogfish shark Squalus Acanthias. Indeed, squalamine has shown to be useful for the treatment of important diseases such as cancers (lung, ovarian, brain and others), age-related macular degeneration (AMD) and the control of body weight in man. All these results led to a question: could we consider squalamine as a polyvalent drug of the future?
Export Options
About this article
Cite this article as:
Brunel Michel Jean, Salmi Chanaz, Loncle Celine, Vidal Nicolas and Letourneux Yves, Squalamine: A Polyvalent Drug of the Future?, Current Cancer Drug Targets 2005; 5 (4) . https://dx.doi.org/10.2174/1568009054064642
DOI https://dx.doi.org/10.2174/1568009054064642 |
Print ISSN 1568-0096 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5576 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Role of Membrane Transporters and Metabolizing Enzymes in Ocular Drug Delivery
Current Drug Metabolism Cell Cycle Arrest and Apoptosis Induction of Phloroacetophenone Glycosides and Caffeoylquinic Acid Derivatives in Gastric Adenocarcinoma (AGS) Cells
Anti-Cancer Agents in Medicinal Chemistry Focal Adhesion Kinase Regulates Expression of Thioredoxin-interacting Protein (TXNIP) in Cancer Cells
Anti-Cancer Agents in Medicinal Chemistry Inhibition of STAT Signalling in Bladder Cancer by Diindolylmethane - Relevance to Cell Adhesion, Migration and Proliferation
Current Cancer Drug Targets Editorial: Towards MiRNA Based Therapeutics for Lung Cancer
Current Pharmaceutical Design Molecular Features, Markers, Drug Targets, and Prospective Targeted Therapeutics in Cardiac Myxoma
Current Cancer Drug Targets Regulation by IFN-α/IFN-γ Co-Formulation (HerberPAG<sup>®</sup>) of Genes Involved in Interferon-STAT-Pathways and Apoptosis in U87MG
Current Topics in Medicinal Chemistry An Overview on Keratinocyte Growth Factor: From the Molecular Properties to Clinical Applications
Protein & Peptide Letters Focal Adhesion Kinase as a Cancer Therapy Target
Anti-Cancer Agents in Medicinal Chemistry Anticancer Potential of Ginger: Mechanistic and Pharmaceutical Aspects
Current Pharmaceutical Design Novel Small Molecule Inhibitors of Programmed Cell Death (PD)-1, and its Ligand, PD-L1 in Cancer Immunotherapy: A Review Update of Patent Literature
Recent Patents on Anti-Cancer Drug Discovery Menopause, A Universal Female Experience: Lessons from Mexico and Central America
Current Women`s Health Reviews The p53-Mdm2 Pathway: Targets for the Development of New Anticancer Therapeutics
Mini-Reviews in Medicinal Chemistry Smart Electrospun Nanofibers for Controlled Drug Release: Recent Advances and New Perspectives
Current Pharmaceutical Design Acknowledgement To Reviewers:
Anti-Cancer Agents in Medicinal Chemistry State of the Art on Carbonic Anhydrase Modulators for Biomedical Purposes
Current Medicinal Chemistry Genome Projects and the Functional-Genomic Era
Combinatorial Chemistry & High Throughput Screening Myeloid Derived Suppressor Cells and Their Role in Diseases
Current Medicinal Chemistry Multidrug Resistance Associated Proteins as Determining Factors of Pharmacokinetics and Pharmacodynamics of Drugs
Current Drug Metabolism Saponins as Tool for Improved Targeted Tumor Therapies
Current Drug Targets