Treatment of Antipsychotic-Induced Hyperprolactinemia: An Update on the Role of the Dopaminergic Receptors D2 Partial Agonist Aripiprazole

Title:Treatment of Antipsychotic-Induced Hyperprolactinemia: An Update on the Role of the Dopaminergic Receptors D2 Partial Agonist Aripiprazole

Volume: 8 Issue: 1

Author(s): Domenico De Berardis, Michele Fornaro, Nicola Serroni, Stefano Marini, Monica Piersanti, Marilde Cavuto, Alessandro Valchera, Monica Mazza, Gabriella Girinelli, Felice Iasevoli, Giampaolo Perna, Giovanni Martinotti and Massimo Di Giannantonio

Affiliation:

Keywords: Add-on, antipsychotics, aripiprazole, dopamine, hyperprolactinaemia, partial agonism, prolactin, switch, update.

Abstract: Hyperprolactinemia is an unwanted adverse effect present in several typical and atypical antipsychotics. Aripiprazole is a drug with partial agonist activity at the level of dopamine receptors D2, which may be effective for antipsychotic- induced hyperprolactinemia. Therefore, we analyzed the literature concerning the treatment of antipsychoticinduced hyperprolactinemia with aripiprazole by updating a previous paper written on the same topic. More recent studies were reviewed. They showed that there are two options for the treatment of antipsychotic-induced hyperprolactinemia with aripiprazole. The safest strategy may require the addition of aripiprazole to ongoing treatments, in the case patients had previously responded to antipsychotic drugs and then developed hyperprolactinemia. However, it is advisable to monitor the patients in case relapses and/or side effect, although rare, might occur. Switching drugs should be considered when a patient does not appear to be responding to the previous antipsychotic, thus developing hyperprolactinemia. A cross-taper switch should always be considered, but the risk of a relapse in the disorder may occur more frequently and the patients should be closely monitored. However, limitations must be considered and further studies are needed to definitely elucidate this important issue. Some relevant patents are also described in this review.

Cite this article as:

Berardis De Domenico, Fornaro Michele, Serroni Nicola, Marini Stefano, Piersanti Monica, Cavuto Marilde, Valchera Alessandro, Mazza Monica, Girinelli Gabriella, Iasevoli Felice, Perna Giampaolo, Martinotti Giovanni and Giannantonio Di Massimo, Treatment of Antipsychotic-Induced Hyperprolactinemia: An Update on the Role of the Dopaminergic Receptors D2 Partial Agonist Aripiprazole, Recent Patents on Endocrine, Metabolic & Immune Drug Discovery (Discontinued) 2014; 8 (1) . https://dx.doi.org/10.2174/1872214807666131229125700