Potent Neuroprotective Activity of Monoterpene Derived 4-[(3aR,7aS)- 1,3,3a,4,5,7a-Hexahydro-3,3,6-trimethylisobenzofuran-1-yl]-2-methoxyphenol in MPTP Mice Model

Title:Potent Neuroprotective Activity of Monoterpene Derived 4-[(3aR,7aS)- 1,3,3a,4,5,7a-Hexahydro-3,3,6-trimethylisobenzofuran-1-yl]-2-methoxyphenol in MPTP Mice Model

Volume: 11 Issue: 5

Author(s): Alla V. Pavlova, Irina V. Il'ina, Ekaterina A. Morozova, Dina V. Korchagina, Svetlana Yu. Kurbakova, Irina V. Sorokina, Tatyana G. Tolstikova, Konstantin P. Volcho and Nariman F. Salakhutdinov

Affiliation:

Keywords: Neuroprotection, Parkinson disease, MPTP, Mice, Monoterpene, Carene, Vanillin.

Abstract: Studies of the neuroprotective activity of a series of monoterpene-derived compounds on the MPTP mice model showed that 4-[(3aR,7aS)-1,3,3a,4,5,7a-hexahydro-3,3,6-trimethylisobenzofuran-1-yl]-2-methoxyphenol 15 possessed a considerable neuroprotective activity. Compound 15 was synthesized by one-stage reaction of (+)-2-carene with vanillin. It has low acute toxicity and significantly decreased the development of catalepsy evoked by haloperidol in rats.

Cite this article as:

Pavlova V. Alla, Il'ina V. Irina, Morozova A. Ekaterina, Korchagina V. Dina, Kurbakova Yu. Svetlana, Sorokina V. Irina, Tolstikova G. Tatyana, Volcho P. Konstantin and Salakhutdinov F. Nariman, Potent Neuroprotective Activity of Monoterpene Derived 4-[(3aR,7aS)- 1,3,3a,4,5,7a-Hexahydro-3,3,6-trimethylisobenzofuran-1-yl]-2-methoxyphenol in MPTP Mice Model, Letters in Drug Design & Discovery 2014; 11 (5) . https://dx.doi.org/10.2174/1570180811666131210000316

DOI https://dx.doi.org/10.2174/1570180811666131210000316	Print ISSN 1570-1808
Publisher Name Bentham Science Publisher	Online ISSN 1875-628X