Abstract
Combination of biomaterials with nanotechnology has been applied to the immobilization of chitosan on nano-gold particles by plasma and grafting treatments. In this study, gold (Au) nanoparticles were first synthesized by chemical reduction method using mixing solution of HAuCl44H2O and sodium citrate or NaBH4. The synthesized gold nanoparticles were then reacted with 11- mercaptoundecanoic acid (MUA) containing thiol group to modify the surface of gold nanoparticle. The MUA-modified Au nanoparticles were subjected to O2 plasma pretreatment before the UV light grafting polymerization with N-Isopropylacrylamide (NIPAAm) on the plasma-treated Au nanoparticles to form a thermosensitive polymer on the surface. The functional groups on the grafted Au nanoparticles surface were combined with glutaraldehyde to immobilize biological molecules of chitosan. The results show that preparation of nano-Au particles using NaBH4 solution as reductant is better than using the sodium citrate solution. The preferable reaction temperature for the preparation using NaBH4 solution to produce nano-Au particles is 100°C. From the TEM observation the prepared Au nanoparticle was spherical-like and about 10~20 nm in size. The zeta potential measurement on the immobilized Au nanoparticles proves that chitosan was indeed immobilized on the Au nanoparticles surface.
Keywords: Chitosan, gold, graft, NIPAAm, plasma, thermosensitive polymer.
Current Nanoscience
Title:Plasma Surface Treatment and Grafting of Nano-Gold Surface for Immobilization of Chitosan
Volume: 10 Issue: 2
Author(s): Hsin-Ming Wu, Yi-Syuan Wei, Ko-Shao Chen and Yi-Jang Liou
Affiliation:
Keywords: Chitosan, gold, graft, NIPAAm, plasma, thermosensitive polymer.
Abstract: Combination of biomaterials with nanotechnology has been applied to the immobilization of chitosan on nano-gold particles by plasma and grafting treatments. In this study, gold (Au) nanoparticles were first synthesized by chemical reduction method using mixing solution of HAuCl44H2O and sodium citrate or NaBH4. The synthesized gold nanoparticles were then reacted with 11- mercaptoundecanoic acid (MUA) containing thiol group to modify the surface of gold nanoparticle. The MUA-modified Au nanoparticles were subjected to O2 plasma pretreatment before the UV light grafting polymerization with N-Isopropylacrylamide (NIPAAm) on the plasma-treated Au nanoparticles to form a thermosensitive polymer on the surface. The functional groups on the grafted Au nanoparticles surface were combined with glutaraldehyde to immobilize biological molecules of chitosan. The results show that preparation of nano-Au particles using NaBH4 solution as reductant is better than using the sodium citrate solution. The preferable reaction temperature for the preparation using NaBH4 solution to produce nano-Au particles is 100°C. From the TEM observation the prepared Au nanoparticle was spherical-like and about 10~20 nm in size. The zeta potential measurement on the immobilized Au nanoparticles proves that chitosan was indeed immobilized on the Au nanoparticles surface.
Export Options
About this article
Cite this article as:
Wu Hsin-Ming, Wei Yi-Syuan, Chen Ko-Shao and Liou Yi-Jang, Plasma Surface Treatment and Grafting of Nano-Gold Surface for Immobilization of Chitosan, Current Nanoscience 2014; 10 (2) . https://dx.doi.org/10.2174/1573413709666131129000228
DOI https://dx.doi.org/10.2174/1573413709666131129000228 |
Print ISSN 1573-4137 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6786 |

- Author Guidelines
- Bentham Author Support Services (BASS)
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Neuroprotective Effects of a Glutathione Depletor in Rat Post-Ischemic Reperfusion Brain Damage
CNS & Neurological Disorders - Drug Targets Ionic Liquid Mediated Tandem Synthesis of Bioactive Quinoline Based Thiophene/ Thiazole Linked Multi-Heterocomponent Ugi Adducts
Current Organic Chemistry Recent Progress on the Applications of Multifunctional Glyconanoparticles
Current Pharmaceutical Design Biodegradable Composite Scaffolds: A Strategy to Modulate Stem Cell Behaviour
Recent Patents on Drug Delivery & Formulation High-Risk HPV/ErbB-2 Interaction on E-Cadherin/Catenin Regulation in Human Carcinogenesis
Current Pharmaceutical Design Synthesis of new 6-Spiro (Testosteron-3′-yl)-Hexahydro-3-Thioxo-1, 2, 3-Triazin-5-Ones and Related Derivatives as Affecting Enzymatic Agents
Current Organic Synthesis Histone Deacetylase Inhibitor Trichostatin A Suppresses Cell Proliferation and Induces Apoptosis by Regulating the PI3K/AKT Signalling Pathway in Gastric Cancer Cells
Anti-Cancer Agents in Medicinal Chemistry HPLC Stability Indicating Assay Method for Metformin Hydrochloride in Bulk Drug and Tablets and Cytotoxicity of Degradation Products
Current Pharmaceutical Analysis Laccases and Their Applications: A Patent Review
Recent Patents on Biotechnology Accelerator Mass Spectrometry in Pharmaceutical Research and Development A New Ultrasensitive Analytical Method for Isotope Measurement
Current Drug Metabolism Bothrops pauloensis Snake Venom Toxins: The Search for New Therapeutic Models
Current Topics in Medicinal Chemistry The Induction and Repair of DNA Interstrand Crosslinks and Implications in Cancer Chemotherapy
Anti-Cancer Agents in Medicinal Chemistry Microarrays and Mass Spectrometry - The Future of Proteomics
Current Genomics Endothelial Endocytic Pathways: Gates for Vascular Drug Delivery
Current Vascular Pharmacology Polymer-Based Drug Delivery Devices for Neurological Disorders
CNS & Neurological Disorders - Drug Targets Different Methods for Molecular and Rapid Detection of Human Novel Coronavirus
Current Pharmaceutical Design Immunotoxicity and Immunogenicity of Biopharmaceuticals: Design Concepts and Safety Assessment
Current Drug Safety Small Molecule Inhibitors of Peptidylprolyl cis/trans Isomerase
Current Enzyme Inhibition Biochemical Markers of Renal Function
Current Medicinal Chemistry An Overview on Chemistry and Biological Importance of Pyrrolidinone
Current Organic Synthesis