An Efficient Synthesis of Some New Hydrazone Derivatives Containing 1,2,3-Triazole and Thiazole

Title:An Efficient Synthesis of Some New Hydrazone Derivatives Containing 1,2,3-Triazole and Thiazole

Volume: 10 Issue: 10

Author(s): Keyume Ablajan, Wang Liju and Anagu Tuoheti

Affiliation:

Keywords: 1, 2, 3-Triazole, thiazole, hydrazone, synthesis, one-pot reaction, bioactivity.

Abstract: The syntheses of hydrazone derivatives with thiazole and triazole rings were described. The target compounds 7a-j and 8a-g with the hydrazine based structure containing thiazole and triazole rings were synthesized respectively through the reactions of α-bromomethylpyrazole ketone 3 with arylethanone thiosemicarbazones 5a-j and the reactions of pyrazol thiosemicarbazone 4 with α-bromomethyl aryl ketones 6a-g under reflux condition without catalyst. Furthermore, an eco-friendly convenient method for the synthesis of compounds 8a-g was developed using one-pot route. The target compounds were tested for preliminary bioactivities by using H₂O₂-induced PC 12 cells with oxidative injury.

Cite this article as:

Ablajan Keyume, Liju Wang and Tuoheti Anagu, An Efficient Synthesis of Some New Hydrazone Derivatives Containing 1,2,3-Triazole and Thiazole, Letters in Organic Chemistry 2013; 10 (10) . https://dx.doi.org/10.2174/157017861010131126115715