Synthesis, Characterization and Antitumor Activity of Novel Triazole/ Isoxazole Tagged Pyridine Hybrids

Title:Synthesis, Characterization and Antitumor Activity of Novel Triazole/ Isoxazole Tagged Pyridine Hybrids

Volume: 11 Issue: 4

Author(s): Raju K, Chandra Shekhar A, Sathaiah G, Ravi Kumar A, Narsaiah B, Shanthan Rao P, Srujana R and Srigiridhar Kotamraju

Affiliation:

Keywords: Nicotinonitrile, propargylation, antitumor activity, 1, 2, 3-triazole, isoxazole.

Abstract: A series of novel 2-((1-substituted-1H-1,2,3-triazol-4-yl/3-substitutedisoxazol-5-yl)methoxy) substituted pyridine, 1-((1-substituted-1H-1,2,3-triazol-4-yl/3-substitutedisoxazol-5-yl)methyl)substituted pyridin-2(1H)-one was prepared from 2-oxo-6-phenyl/methyl-4-(trifluoromethyl)-1,2-dihydropyridine-3-carbonitrile 3 via propargylation followed by 1,3- dipolar cycloaddition of the propargyl derivatives 4 and 5. These triazole/isoxazole tagged pyridine derivatives were evaluated for antitumor activity against breast cancer cell lines such as MDA-MB-231, MCF-7 etc. The results indicated that compounds 6e, 6f, 8e and 8f were found to be active on MDA-MB-231, while 6h and 8h were active on MCF-7.

Cite this article as:

K Raju, A Shekhar Chandra, G Sathaiah, A Kumar Ravi, B Narsaiah, P Rao Shanthan, R Srujana and Kotamraju Srigiridhar, Synthesis, Characterization and Antitumor Activity of Novel Triazole/ Isoxazole Tagged Pyridine Hybrids, Letters in Organic Chemistry 2014; 11 (4) . https://dx.doi.org/10.2174/1570178610666131118223356