Inflammatory-Mediated Injury and Repair in the Traumatically Injured Spinal Cord

Title: Inflammatory-Mediated Injury and Repair in the Traumatically Injured Spinal Cord

Volume: 11 Issue: 10

Author(s): T. B. Jones, E. E. McDaniel and P. G. Popovich

Affiliation:

Keywords: inflammation, spinal cord injury, neuroprotection, immunology, pathology

Abstract: Spinal cord trauma activates the immune system and elicits leukocyte recruitment to the site of injury. This increase in immunological activity contributes to acute lesion expansion over a period of days to weeks following the initial trauma. At the same time, inflammatory cells and mediators facilitate endogenous repair processes such as axonal sprouting and remyelination. Thus, to be effective, therapies that target the immune system must limit the destructive effects of neutrophil, macrophage and lymphocyte activation, while simultaneously preserving their reparative functions.

Cite this article as:

Jones B. T., McDaniel E. E. and Popovich G. P., Inflammatory-Mediated Injury and Repair in the Traumatically Injured Spinal Cord, Current Pharmaceutical Design 2005; 11 (10) . https://dx.doi.org/10.2174/1381612053507468