Synthesis and Anti-tumor Activity Evaluation of Gallic Acid-mangiferin Hybrid Molecule

Xiang-yu      Hu; Jia-gang      Deng; Lin      Wang; Ye-fei      Yuan

doi:10.2174/1573406411309080007

Abstract

To improve the anti-tumor effects of gallic acid and mangiferin, a gallic acid-mangiferin hybrid molecule (GAMA) was synthesized from gallic acid with mangiferin in the presence of ionic liquid ChC1(choline chloride)·2SnC1₂. Chemical and spectroscopic methods, such as ¹H and ¹³C NMR spectroscopy, and HR-ESIMS were used for the structure identification of GA-MA. Using the cell counting kit-8 (CCK-8) assay, the in vitro anti-tumor effects were compared between GA-MA, gallic acid and mangiferin on human hepatoma HepG2, human nasopharyngeal carcinoma CNE, human lung cancer NCI-H460, human ovarian cancer SK-OV-3, and human cervical cancer Hela cells. The results showed that the half inhibitory concentration (IC₅₀) of GA-MA on HepG2, CNE, NCI-H460, SK-OV-3, and Hela cells was significantly lower than that of gallic acid or mangiferin. This showed that GA-MA has a better in vitro anti-tumor effect than gallic acid and mangi-ferin.

Keywords: Gallic acid, mangiferin, gallic acid-mangiferin hybrid molecule.

« Previous Next »