Abstract
Using organometallic chemistry several novel methods for the efficient construction of pyrroles, indoles, and carbazoles have been developed. The key reactions are transition metal-mediated or -catalyzed oxidative cyclizations and cycloadditions. In the present article we summarize some recent applications of these methods to short and convergent total syntheses of naturally occurring biologically active alkaloids including fused indolizidines, yohimbanes, Amaryllidaceae alkaloids, and carbazoles.
Keywords: oxidative cyclizations, diels-alder cycloaddition, diyens, cyclopentadienones, carbazole alkaloids, fused indolizidine alkaloids
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
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