Abstract
Pyrroles and gem-dihalocyclopropanes are both readily accessible classes of compound. They have considerable potential as building blocks in the construction of alkaloid frameworks. This review details work, carried out within the authors laboratories, directed towards such ends and with a particular emphasis on the engagement of the title moieties in intramolecular processes. An emerging area involving efforts to exploit the complementary electronic characteristics of pyrroles and gem-dihalogenocyclopropanes in the synthesis of alkaloids is also discussed.
Keywords: natural products chemistry, didemnum sp, marine alkaloids, longamide, intramolecular michael addition reactions, rhazinal, lycoricidine
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
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