Abstract
A set of new polyoxo 2-benzyl-2,3-dihydrobenzofurans and their related compounds, including 2- benzylbenzofuran-3(2H)-ones and 2-benzylbenzofurans, were designed and synthesized. Their antiproliferative activities were evaluated against human gastric cancer (SGC-7901), human fibrosarcoma (HT-1080) and human oral epidermoid carcinoma (KB) cell lines in vitro. Preliminary results showed that some polyoxo 2-benzyl-2,3-dihydrobenzofurans and their related compounds had significant activity comparable with that of cisplatin.
Keywords: Antiproliferative activity, Synthesis, Aurone, 2-Benzyl-2, 3-dihydrobenzofuran, 2-Benzylbenzofuran-3(2H)-ones, 2-Benzylbenzofurans.
Letters in Drug Design & Discovery
Title:Synthesis and Antiproliferative Activity of New Polyoxo 2-Benzyl-2,3- dihydrobenzofurans and Their Related Compounds
Volume: 10 Issue: 9
Author(s): Ping Qi, Jianhua Jiang, Huan Qi, Yinghua Jin, Qirong Shen, Yingliang Wu, Hongrui Song and Weige Zhang
Affiliation:
Keywords: Antiproliferative activity, Synthesis, Aurone, 2-Benzyl-2, 3-dihydrobenzofuran, 2-Benzylbenzofuran-3(2H)-ones, 2-Benzylbenzofurans.
Abstract: A set of new polyoxo 2-benzyl-2,3-dihydrobenzofurans and their related compounds, including 2- benzylbenzofuran-3(2H)-ones and 2-benzylbenzofurans, were designed and synthesized. Their antiproliferative activities were evaluated against human gastric cancer (SGC-7901), human fibrosarcoma (HT-1080) and human oral epidermoid carcinoma (KB) cell lines in vitro. Preliminary results showed that some polyoxo 2-benzyl-2,3-dihydrobenzofurans and their related compounds had significant activity comparable with that of cisplatin.
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Qi Ping, Jiang Jianhua, Qi Huan, Jin Yinghua, Shen Qirong, Wu Yingliang, Song Hongrui and Zhang Weige, Synthesis and Antiproliferative Activity of New Polyoxo 2-Benzyl-2,3- dihydrobenzofurans and Their Related Compounds, Letters in Drug Design & Discovery 2013; 10 (9) . https://dx.doi.org/10.2174/15701808113109990011
DOI https://dx.doi.org/10.2174/15701808113109990011 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
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