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Letters in Organic Chemistry

Editor-in-Chief

ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

Synthesis of Methylenebisamides by TFA-Promoted Reactions of Nitriles and DMSO

Author(s): Lingxia Pan, Lin Huang and Chunsong Xie

Volume 10, Issue 10, 2013

Page: [770 - 773] Pages: 4

DOI: 10.2174/15701786113109990049

Price: $65

Abstract

Under TFA promoted conditions, aryl and 2-pyridyl nitriles can react with DMSO, affording methylenebisamides in moderate to good yields. While the electron-donating groups give good yields, the electron-withdrawing groups provide lower yields.

Keywords: Methylenebisamide, nitrile, DMSO.


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