Synthesis, Antibacterial, Antifungal and Antitubercular Activities of N-Pyrazolylbenzamide Derivatives

Title:Synthesis, Antibacterial, Antifungal and Antitubercular Activities of N-Pyrazolylbenzamide Derivatives

Volume: 10 Issue: 2

Author(s): Ravindra Kulkarni, Vijaykumar, Harish Babu, Krishna Kumar, Naveen Gaddam, Aneesa Fatima, Sudhakar Muvvala, Bhikshapathi D V R N, Sriram D, Achaiah Garlapati, Jagrut Vishnav and Prashant Gurav

Affiliation:

Keywords: Benzamides, antibacterial, antifungal, antitubercular.

Abstract: A series of new N-pyrazolylbenzamides (5a–x) were synthesized by aroylation of 5-amino-1-phenyl-3-tbutylpyrazole. The structures of synthesized compounds were established based on spectral (FTIR, ¹H NMR, ESI Mass) analysis and purity was ascertained by HPLC. The antibacterial screening revealed that seven molecules exhibited an excellent antibacterial activity and eight compounds demonstrated considerable antifungal activity. Three molecules of the series 5e, 5s and 5w were found to be highly effective against Klebsilla pneumoneia with MIC of 3.12 µg/ml. Compounds 5b, 5f, 5g and 5o exhibited significant antitubercular activity with MIC of 12.5 µg/ml.

Cite this article as:

Kulkarni Ravindra, Vijaykumar , Babu Harish, Kumar Krishna, Gaddam Naveen, Fatima Aneesa, Muvvala Sudhakar, N D V R Bhikshapathi, D Sriram, Garlapati Achaiah, Vishnav Jagrut and Gurav Prashant, Synthesis, Antibacterial, Antifungal and Antitubercular Activities of N-Pyrazolylbenzamide Derivatives, Medicinal Chemistry 2014; 10 (2) . https://dx.doi.org/10.2174/15734064113099990039