Abstract
A technical improvement enabling efficient and reproducible stem cell cultures is one of the most important aspects in stem cell research and cell-based therapy. For this purpose, researchers have used various cytokine cocktails and gene transfection techniques to proliferate stem cells. However, stem cell fate can reportedly be determined by physical stimuli such as gravity, electrical fields, and magnetic fields. In this regard, we have developed a novel technique utilizing a clinostat, a device capable of generating a controlled microgravity environment for robust maintenance of stem cell state. Here, we review our recent progress in expansion and differentiation of stem cells grown under simulated microgravity environment and their utility for transplantation in animal models of cartilage deficiency and neurotrauma.
Keywords: Simulated microgravity, stem cell, cell differentiation, cell-based therapy.
Current Biotechnology
Title:Simulated Microgravity Based Stem Cell Cultures Enhance Their Utility for Cell-Based Therapy
Volume: 2 Issue: 3
Author(s): Yumi Kawahara and Louis Yuge
Affiliation:
Keywords: Simulated microgravity, stem cell, cell differentiation, cell-based therapy.
Abstract: A technical improvement enabling efficient and reproducible stem cell cultures is one of the most important aspects in stem cell research and cell-based therapy. For this purpose, researchers have used various cytokine cocktails and gene transfection techniques to proliferate stem cells. However, stem cell fate can reportedly be determined by physical stimuli such as gravity, electrical fields, and magnetic fields. In this regard, we have developed a novel technique utilizing a clinostat, a device capable of generating a controlled microgravity environment for robust maintenance of stem cell state. Here, we review our recent progress in expansion and differentiation of stem cells grown under simulated microgravity environment and their utility for transplantation in animal models of cartilage deficiency and neurotrauma.
Export Options
About this article
Cite this article as:
Kawahara Yumi and Yuge Louis, Simulated Microgravity Based Stem Cell Cultures Enhance Their Utility for Cell-Based Therapy, Current Biotechnology 2013; 2 (3) . https://dx.doi.org/10.2174/22115501113029990020
DOI https://dx.doi.org/10.2174/22115501113029990020 |
Print ISSN 2211-5501 |
Publisher Name Bentham Science Publisher |
Online ISSN 2211-551X |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Green Tea, A Medicinal Food with Promising Neurological Benefits
Current Neuropharmacology Potential Therapeutic Application of Chondroitin Sulfate/Dermatan Sulfate
Current Drug Discovery Technologies Noradrenergic System in Down Syndrome and Alzheimer’s Disease A Target for Therapy
Current Alzheimer Research Dental Pulp from Human Exfoliated Deciduous Teeth-derived Stromal Cells Demonstrated Neuronal Potential: In Vivo and In Vitro Studies
Current Stem Cell Research & Therapy Innovative Formulations for the Controlled and Site-specific Delivery of Antiinflammatory Drugs
Current Pharmaceutical Design Opening New Scenarios for Human MAO Inhibitors
Central Nervous System Agents in Medicinal Chemistry Phosphodiesterases as Therapeutic Targets for Huntington’s Disease
Current Pharmaceutical Design Bridging the Gap: The Potential Role of Corticosteroid Binding Globulin in Cardiac Steroid Facilitation
Current Drug Targets Cerebrospinal Fluid Proteomes: From Neural Development to Neurodegenerative Diseases
Current Proteomics Use of Human Umbilical Cord Blood (HUCB) Cells to Repair the Damaged Brain
Current Neurovascular Research Overactive Bladder Syndrome, Detrusor Overactivity and the Botulinum Toxin
Reviews on Recent Clinical Trials Targeting Cyclooxygenase and Nitric Oxide Pathway Cross-Talk: A New Signal Transduction Pathway for Developing More Effective Anti- Inflammatory Drugs
Current Signal Transduction Therapy Metabolic Control of Type 2 Diabetes by Targeting the GLUT4 Glucose Transporter: Intervention Approaches
Current Pharmaceutical Design Selective Chemokine Receptor-Targeted Depletion of Pathological Cells as A Therapeutic Strategy for Inflammatory, Allergic and Autoimmune Diseases
Recent Patents on Inflammation & Allergy Drug Discovery The Association of Neuronal Stress with Activating Transcription Factor 3 in Dorsal Root Ganglion of in vivo and in vitro Models of Bortezomib- Induced Neuropathy
Current Cancer Drug Targets Proteins in Microglial Activation - Inputs and Outputs by Subsets
Current Protein & Peptide Science Palmitoylethanolamide Restores Myelinated-Fibre Function in Patients with Chemotherapy-Induced Painful Neuropathy
CNS & Neurological Disorders - Drug Targets Computational Models of Neuronal Biophysics and the Characterization of Potential Neuropharmacological Targets
Current Medicinal Chemistry Pharmacological and Biological Therapies for Metabolic Bone Disease in Critical Illness: An Integrative Physiology Approach
Current Drug Therapy Pitfalls and Solutions for the Validation of Novel Drugs in Animal Models of Disease
Current Immunology Reviews (Discontinued)