Abstract
This review article summarizes the recent information regarding general aspects in the automated synthesis of 18F-labelled PET radiotracers that are prepared via nucleophilic fluorination pathway. The previous and on-going researches in development of different automation solutions are discussed and the current trends in large scale production of radiotracers are considered. The advantages and limitations of the fully automated systems available from different manufacturers are exemplified by routine automated production of several clinically relevant 18F-radiotracers using traditional automated synthesizers, kit-based (cassette-type) radiochemistry modules and modular systems.
Keywords: Automation, F-18, Nucleophilic fluorination, PET radiopharmaceuticals, Synthesis modules.
Current Organic Chemistry
Title:PET Radiochemistry Automation: State of the Art and Future Trends in 18F-nucleophilic Fluorination
Volume: 17 Issue: 19
Author(s): Raisa Krasikova
Affiliation:
Keywords: Automation, F-18, Nucleophilic fluorination, PET radiopharmaceuticals, Synthesis modules.
Abstract: This review article summarizes the recent information regarding general aspects in the automated synthesis of 18F-labelled PET radiotracers that are prepared via nucleophilic fluorination pathway. The previous and on-going researches in development of different automation solutions are discussed and the current trends in large scale production of radiotracers are considered. The advantages and limitations of the fully automated systems available from different manufacturers are exemplified by routine automated production of several clinically relevant 18F-radiotracers using traditional automated synthesizers, kit-based (cassette-type) radiochemistry modules and modular systems.
Export Options
About this article
Cite this article as:
Krasikova Raisa, PET Radiochemistry Automation: State of the Art and Future Trends in 18F-nucleophilic Fluorination, Current Organic Chemistry 2013; 17 (19) . https://dx.doi.org/10.2174/13852728113179990102
DOI https://dx.doi.org/10.2174/13852728113179990102 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
miRNAs in Melanoma: Tumor Suppressors and Oncogenes with Prognostic Potential
Current Medicinal Chemistry Clinical Applications of Gene Therapy in Head and Neck Cancer
Current Gene Therapy Virus as a Nanocarrier for Drug Delivery Redefining Medical Therapeutics - A Status Report
Combinatorial Chemistry & High Throughput Screening Lanreotide and its Potential Applications in Polycystic Kidney and Liver Diseases
Current Topics in Medicinal Chemistry Long Non-Coding RNAs As Epigenetic Regulators in Cancer
Current Pharmaceutical Design Treatment of Estrogen Receptor-Positive Breast Cancer
Current Medicinal Chemistry Natural-based Hydrogels: A Journey from Simple to Smart Networks for Medical Examination
Current Medicinal Chemistry Inhibition of Transcription Factors by Plant-Derived Compounds and their Implications in Inflammation and Cancer
Current Pharmaceutical Design Fish Hydrolysates: A Regulatory Perspective of Bioactive Peptides
Protein & Peptide Letters Oxygen-independent Regulation of HIF-1: Novel Involvement of PI3K/ AKT/mTOR Pathway in Cancer
Current Cancer Drug Targets Telomeres, Senescence and Longevity: The Role of Oxidative Stress and Antioxidants
Current Pharmacogenomics The Adipocyte as a Novel TSH Target
Mini-Reviews in Medicinal Chemistry Neuropeptide - Adipose Tissue Communication and Intestinal Pathophysiology
Current Pharmaceutical Design Multifunctional Proteins in Tumorigenesis: Aminoacyl-tRNA Synthetases and Translational Components
Current Proteomics The Role of Chromogranin A (CgA) in Monitoring Patients with Prostate Cancer Under Androgen Deprivation Therapy: Comparison with Prostatic Specific Antigen (PSA)
Current Radiopharmaceuticals Patent Perspective for Potential Antioxidant Compounds-Rutin and Quercetin
Recent Patents on Nanomedicine The Chemokine Receptor CXCR4 as a Therapeutic Target for Several Diseases
Mini-Reviews in Medicinal Chemistry Preclinical Drug Metabolism and Pharmacokinetics, and Prediction of Human Pharmacokinetics and Efficacious Dose of the Investigational Aurora A Kinase Inhibitor Alisertib (MLN8237)
Drug Metabolism Letters Clioquinol – A Novel Copper-Dependent and Independent Proteasome Inhibitor
Current Cancer Drug Targets Abelson Tyrosine-Protein Kinase 1 as Principal Target for Drug Discovery Against Leukemias. Role of the Current Computer-Aided Drug Design Methodologies
Current Topics in Medicinal Chemistry