Abstract
This paper revisits some aspects of carbon-11 radiochemistry from the production of the primary labeling reagents and fast chemical transformations used to convert them into more useful building blocks such as [11C]methyl iodide and [11C]carbon monoxide. The application facet covers traditional methylation, carboxylation and other reactions in the preparation of PET tracers. Technical aspects and strategies in handling labeling syntheses are also included. Distinct attention is then given to methods for the 11C-labelling of carbamide and carbamate functional groups at the carbonyl position, considering the wide choice of protocols and starting materials that have become available for this purpose. Concluding sections provide an overview of contemporary practices for the purification of labeled compounds and preventing their radiolytic decomposition.
Keywords: Carbon-11, Radiochemistry, Positron Emission Tomography, PET, Review.
Current Organic Chemistry
Title:On 11C Chemistry Reviews - Surveying and Filling the Gaps
Volume: 17 Issue: 19
Author(s): Oleksiy Itsenko, Vanessa Goméz-Vallejo, Jordi Llop and Jacek Koziorowski
Affiliation:
Keywords: Carbon-11, Radiochemistry, Positron Emission Tomography, PET, Review.
Abstract: This paper revisits some aspects of carbon-11 radiochemistry from the production of the primary labeling reagents and fast chemical transformations used to convert them into more useful building blocks such as [11C]methyl iodide and [11C]carbon monoxide. The application facet covers traditional methylation, carboxylation and other reactions in the preparation of PET tracers. Technical aspects and strategies in handling labeling syntheses are also included. Distinct attention is then given to methods for the 11C-labelling of carbamide and carbamate functional groups at the carbonyl position, considering the wide choice of protocols and starting materials that have become available for this purpose. Concluding sections provide an overview of contemporary practices for the purification of labeled compounds and preventing their radiolytic decomposition.
Export Options
About this article
Cite this article as:
Itsenko Oleksiy, Goméz-Vallejo Vanessa, Llop Jordi and Koziorowski Jacek, On 11C Chemistry Reviews - Surveying and Filling the Gaps, Current Organic Chemistry 2013; 17 (19) . https://dx.doi.org/10.2174/13892029113149990101
DOI https://dx.doi.org/10.2174/13892029113149990101 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
Chemistry and Biology of Carbohydrates
Carbohydrates are one of the most abundant natural products and are considered to be extremely important biomolecules for their ever-increasing impact on chemistry and biology. Their role in several important biological processes, notably energy storage, transport, modulation of protein function, intercellular adhesion, malignant transformation, signal transduction, viral, and bacterial cell ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
The Synthetic Cannabinoids Phenomenon
Current Pharmaceutical Design Diallyl Sulfide: Potential Use in Novel Therapeutic Interventions in Alcohol, Drugs, and Disease Mediated Cellular Toxicity by Targeting Cytochrome P450 2E1
Current Drug Metabolism Pharmacological Activities and Therapeutic Potential of Kaempferitrin in Medicine for the Treatment of Human Disorders: A Review of Medicinal Importance and Health Benefits
Cardiovascular & Hematological Disorders-Drug Targets Application of Stem Cells in Cardiology: Where we are and where we are Going
Current Stem Cell Research & Therapy From Bone to Brain: Human Skeletal Stem Cell Therapy for Stroke
Central Nervous System Agents in Medicinal Chemistry Preconditioning with Chronic Cerebral Hypoperfusion Reduces a Focal Cerebral Ischemic Injury and Increases Apurinic/Apyrimidinic Endonuclease/Redox Factor-1 and Matrix Metalloproteinase-2 Expression
Current Neurovascular Research Cardioprotective Potential of Iron Chelators and Prochelators
Current Medicinal Chemistry Mechanisms of Cardiovascular Changes in an Experimental Model of Syndrome X and Pharmacological Intervention on the Renin-Angiotensin- System
Current Vascular Pharmacology Prognostic Value of Copeptin in Chronic Kidney Disease: From General Population to End-Stage Renal Disease
Current Protein & Peptide Science Platelet in Progression of Atherosclerosis: A Potential Target in Diabetic Patients
Current Diabetes Reviews Heat Shock Proteins in Diabetes and Wound Healing
Current Protein & Peptide Science Deep Inspiration Breath-hold (DIBH) Technique to Reduce Cardiac Radiation Dose in the Management of Breast Cancer
Current Cancer Therapy Reviews Guide of Hypertensive Crisis Pharmacotherapy
Cardiovascular & Hematological Disorders-Drug Targets Heme Oxygenase-Derived Carbon Monoxide Restores Vascular Function in Type 1 Diabetes
Drug Metabolism Letters Kawasakis Disease, Acrodynia, and Mercury
Current Medicinal Chemistry Imaging of Integrins as Biomarkers for Tumor Angiogenesis
Current Pharmaceutical Design Stem Cell Therapy: A Promising Approach in Treatment of COVID-19
Current Stem Cell Research & Therapy Cardiovascular Disease in Juvenile Idiopathic Arthritis
Current Vascular Pharmacology The Role of Calcium Handling Mechanisms in Reperfusion Injury
Current Pharmaceutical Design Cannabinoids and Cardiovascular Disease: The Outlook for Clinical Treatments
Current Vascular Pharmacology