Abstract
A new proline derivative of (S)-5-prolylamide-triazole was synthesized and evaluated as an organocatalyst for the direct asymmetric aldol reaction of acetone with aromatic aldehydes under no extra solvent. At room temperature and in the absence of extra solvent, 15 mol% catalyst efficiently catalyzed the direct asymmetric aldol reactions to give aldol adducts, with modest enantiomeric excess (ee) of up to 74%. The titled reactions can be carried out in an environmentally friendly manner of no extra solvent and less catalyst loading.
Keywords: Asymmetric aldol reaction, Enantiomeric excess (ee) value, Organocatalyst, Proline derivative, (S)-5-prolylamide-triazole.
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
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