Abstract
Chiral chromans and flavanones derivatives are widely exist in plants, asymmetric synthesis of biological active chiral flavanone and chromanone derivatives is a valuable research field. A chroman derivatived (+)-(S,R,R,R)-Nebivolol (β1-adrenergic receptor blocker) has been synthesized by natural chiron and sulfoxide-directed method recently. Enantioselective method for the synthesis of flavanones and chromanones by the oxa-Michael addition and other cyclization reactions are described, asymmetric Michael-Michael cascade reaction for the construction of chiral chromans provideas a novel method in the synthesis of chiral flavanones and chromanones. Trost’s AAA reaction (Pd-catalyzed asymmetric allylic alkylation) provides a novel strategies in the synthesis of flavanones and chromanones.
Keywords: Asymmetric synthesis, Cyclization, Michael addition, Cascade reaction, AAA reaction.
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
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