Abstract
Microfluidic systems provide powerful tools for controlling the in vitro cellular microenvironment which best mimick the in vivo biological matrix. Such devices have been applied to both temporal and spatial manipulation of cell growth and stimuli by micro-scaled channels, patterns, and fluidic systems, creating new opportunities for biologists to study cellular behaviors under different physical and chemical conditions. In this paper, we review the concepts and strategies in designing microfluidic devices for culturing, manipulating, and stimulating cells under well-established microenvironments. We further discuss their various biological applications and potential integrations with other observation- based systems.
Keywords: Microfluidic, Cell culture, Lap-on-chip, Chemotaxis, Electrotaxis, Super-resolution microscopy.
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