Computational Methods in Determination of Pharmacophore Models of 5-HT_1A, 5-HT_2A and 5-HT₇ Receptors

Title:Computational Methods in Determination of Pharmacophore Models of 5-HT_1A, 5-HT_2A and 5-HT₇ Receptors

Volume: 13 Issue: 7

Author(s): Anna Bielenica, Anna E. Koziol and Marta Struga

Affiliation:

Keywords: arylpiperazine, pharmacophore model, 5-HT_1A receptor, 5-HT_2A receptor, 5-HT₇ receptor.

Abstract: The present paper discusses models of 5-HT_1A and 5-HT_2A receptors, developed by conformational analysis and 3D-QSAR methods. Hypotheses concerning the ligand-5-HT₇ receptor interaction were complemented by models constructed on the basis of the receptor's structure. Various pharmacophore concepts are supported by structures of exemplary ligands and groups of compounds, derived from chain polycyclic arylpiperazines, used for models generations.

Cite this article as:

Bielenica Anna, E. Koziol Anna and Struga Marta, Computational Methods in Determination of Pharmacophore Models of 5-HT_1A, 5-HT_2A and 5-HT₇ Receptors, Mini-Reviews in Medicinal Chemistry 2013; 13 (7) . https://dx.doi.org/10.2174/1389557511313070001