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Current Pharmaceutical Design

Editor-in-Chief

ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

Fibroblast Growth Factor-2, Bone Homeostasis and Fracture Repair

Author(s): Yurong Fei, Gloria Gronowicz and Marja M. Hurley

Volume 19, Issue 19, 2013

Page: [3354 - 3363] Pages: 10

DOI: 10.2174/1381612811319190002

Price: $65

Abstract

There remains a great need to develop therapeutic agents to treat critical size defects and non-union fractures and one of the potential agents is recombinant human fibroblast growth factor 2 (FGF-2). We discuss the function of FGF-2 in bone formation, bone resorption, and downstream signaling pathways and review the role of exogenous FGF-2 in fracture healing. The importance of endogenous FGF-2 in bone formation and its potential importance in fracture healing in response to parathyroid hormone (PTH) and bone morphogenetic protein 2 (BMP2) is described. In addition we will review, FGF-2 signaling crosstalk with Wnt signaling and PTH signaling in bone formation and repair. Finally, we discuss the outstanding unresolved issues in the application of FGF-2 as therapeutic agent for bone regeneration.

Keywords: FGF-2, Bone Homeostasis, Fracture Repair.


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