Highly Resolution of Propranolol Using Oxidized Multi-walled Carbon Nanotubes and β-cyclodextrin Derivatives as Impregnating Reagents

Title:Highly Resolution of Propranolol Using Oxidized Multi-walled Carbon Nanotubes and β-cyclodextrin Derivatives as Impregnating Reagents

Volume: 9 Issue: 2

Author(s): Xiao-Qing Chen, Cong-Hao Sun, Fei-Peng Jiao, Jin-Gang Yu and Xin-Yu Jiang

Affiliation:

Keywords: Methyl-β-cyclodextrin, hydroxypropyl-β-cyclodextrin, oxidized multi-walled carbon nanotubes, thin-layer chromatography, resolution.

Abstract: By using oxidized multi-walled carbon nanotubes and β-cyclodextrin derivatives (methyl-β-cyclodextrin or hydroxypropyl-β- cyclodextrin) as impregnating reagents, high efficiently resolution of (±)-propranolol, a kind of commonly used β-blockers, has been achieved on abovementioned reagents impregnated silica gel GF254 layers. The solvent system tert-butanol-acetonitrile with various volume ratios was further investigated. By detecting the spots at 254 nm with a UV lamp, the obtained chiral separation factors indicated oxidized multi-walled carbon nanotubes and β-cyclodextrin derivatives impregnated TLC plates could be used for effectively chiral recognition of racemic compounds.

Cite this article as:

Chen Xiao-Qing, Sun Cong-Hao, Jiao Fei-Peng, Yu Jin-Gang and Jiang Xin-Yu, Highly Resolution of Propranolol Using Oxidized Multi-walled Carbon Nanotubes and β-cyclodextrin Derivatives as Impregnating Reagents, Current Nanoscience 2013; 9 (2) . https://dx.doi.org/10.2174/1573413711309020009