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Current Organic Chemistry

Editor-in-Chief

ISSN (Print): 1385-2728
ISSN (Online): 1875-5348

Click-Chemistry in Biocatalysis

Author(s): Jose M. Palomo

Volume 17, Issue 7, 2013

Page: [691 - 700] Pages: 10

DOI: 10.2174/1385272811317070005

Abstract

The application of specific chemical strategies to alter the structure of enzymes in order to improve their catalytic properties in different biotransformations has been a central role in biocatalysis in recent years. Particularly, cycloaddition reactions have represented a successfully methodology for enzyme chemistry because it is chemoselective and extremely rate-accelerated in aqueous media. Some of the most current examples in the use of click chemistry for site-specific modification and immobilization of enzymes has been reviewed in the present article.

Keywords: 1, 3-dipolar cycloaddition, Diels-Alder reaction, chemical modification, biocatalysis, biotransformations, selectivity, chemoselectivity, enatioselectivity.


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