Abstract
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by marked atrophy of cortex and loss of cortical and subcortical neurons. At least two Casein Kinase 1 isoforms have been implicated in the pathogenesis of AD. The ligand-based virtual screening (LBVS) technique uses the information of a set of actives, focusing on the activity of this group of molecules against the desired target. Generally, this type of technique is used when there is no information on the three dimensional structure of the target. However, the use of LBVS allied with three-dimensional information of the protein binding site provides a more accurate screening, since the information of the active site is taken into account during the analysis of results.
Keywords: Alzheimer, virtual screening
Current Bioactive Compounds
Title:Pharmacophore, Similarity and ADMET Screening of Casein Kinase 1 inhibitors in Alzheimer's Disease
Volume: 9 Issue: 1
Author(s): R. P. Rodrigues and C.H.T.P. Silva
Affiliation:
Keywords: Alzheimer, virtual screening
Abstract: Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by marked atrophy of cortex and loss of cortical and subcortical neurons. At least two Casein Kinase 1 isoforms have been implicated in the pathogenesis of AD. The ligand-based virtual screening (LBVS) technique uses the information of a set of actives, focusing on the activity of this group of molecules against the desired target. Generally, this type of technique is used when there is no information on the three dimensional structure of the target. However, the use of LBVS allied with three-dimensional information of the protein binding site provides a more accurate screening, since the information of the active site is taken into account during the analysis of results.
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Cite this article as:
Rodrigues R. P. and Silva C.H.T.P., Pharmacophore, Similarity and ADMET Screening of Casein Kinase 1 inhibitors in Alzheimer's Disease, Current Bioactive Compounds 2013; 9 (1) . https://dx.doi.org/10.2174/1573407211309010005
DOI https://dx.doi.org/10.2174/1573407211309010005 |
Print ISSN 1573-4072 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6646 |
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