Piperidin-4-one: The Potential Pharmacophore

Title:Piperidin-4-one: The Potential Pharmacophore

Volume: 13 Issue: 4

Author(s): Shashi Kant Sahu, Bidhyut Kumar Dubey, Avinash C. Tripathi, Mary Koshy and Shailendra K. Saraf

Affiliation:

Keywords: Piperidin-4-one, Mannich reaction, stereochemistry, anticancer, antiviral, antimicrobial, pyridopyrimidinethione, dimethylformamide

Abstract: The piperidin-4-ones have been reported as versatile intermediates. They have been synthesized using a variety of methods, including Mannich reaction and stereoselective synthesis. The piperidin-4-ones have been reported to possess various pharmacological activities, including anticancer and anti HIV activities. The pharmacophore can be suitably modified in order to achieve better receptor interactions and biological activities. The renewed interest in the nucleus has re-established the importance of piperidin-4-ones in medicinal chemistry. The review intends to discuss the current research trends in the synthetic protocols, characterization, stereochemistry and important biological activities of piperidin-4-ones during the last decade.

Cite this article as:

Kant Sahu Shashi, Kumar Dubey Bidhyut, C. Tripathi Avinash, Koshy Mary and K. Saraf Shailendra, Piperidin-4-one: The Potential Pharmacophore, Mini-Reviews in Medicinal Chemistry 2013; 13 (4) . https://dx.doi.org/10.2174/1389557511313040009