Generic placeholder image

Current Topics in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1568-0266
ISSN (Online): 1873-4294

Can Targeted Therapy be Successful without Metronomic Scheduling ?

Author(s): Nicolas Andre, Eddy Pasquier and Barton Kamen

Volume 12, Issue 15, 2012

Page: [1639 - 1642] Pages: 4

DOI: 10.2174/156802612803531432

Price: $65

Abstract

In medical oncology, targeted therapy has emerged over the last decade, as the most promising strategy to fight cancer. In addition, a more complete understanding of tumor heterogeneity and pharmacology of the more conventional anti-cancer agents has led to development of metronomic chemotherapy (MC) (i.e. a more frequent administration of anticancer agents at lower doses then the usual maximally tolerated dose because it has been realized that time of exposure to an effective drug concentration is more important than simply the dose/m2 or kg.), Here, we discuss the nature of the specificity of targeted anti-cancer treatments and conclude that optimizing the schedule is an effective way to improve treatment selectivity.

Keywords: Metronomic, targeted therapy, cancer, MTD, chemotherapy, oncology, specificity of targeted anti-cancer treatments, treatment selectivity


Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy