Therapeutic Gene Products Delivery by Neuron Stem Cells

Jie      Tan; Yanna      Meng; Shiang      Huang; Ping      Wang

doi:10.2174/138920112803341806

Abstract

Malignant tumors remain virtually untreatable and inevitably lethal despite extensive surgical excision and adjuvant radio- and chemotherapy. Therefore, the development of more effective tumor-selective therapies is necessary. Stem/progenitorcells that self-renew, differentiate and display inherent tumor-tropic properties can be exploited for targeted delivery of therapeutic genes to invasive and metastatic tumors. In this review, we mainly introduce the application in Glioma, Breast cancer, Spinal cord injury, AD and so on. The promising field of stem cell research as it applies to regenerative medicine is still in infancy, but its potential appears limitless, and we are blessed to be involved in this exciting realm of research.

Keywords: Stem/progenitor cells, malignant tumors, gene therapy, antibody neural disorder, chemotherapy, metastatic tumors, Breast cancer, Spinal cord injury, stem cell, The nervous system, neural stem cells, fetal tissue, human ntera 2 neurons, gene products