Abstract
Current evidence indicates that angiogenesis plays an important role in the pathogenesis of several malignancies, including breast cancer. Bevacizumab is a monoclonal antibody that targets the vascular endothelial growth factor (VEGF). Recent clinical data have demonstrated that the addition of bevacizumab to first-line chemotherapy improves the progression-free survival of patients with advanced breast cancer. This review presents an update on the role of bevacizumab, as well as other anti-angiogenic agents in the management of patients with breast carcinoma.
Keywords: Angiogenesis, bevacizumab, breast cancer, treatment.
Mini-Reviews in Medicinal Chemistry
Title:Angiogenesis as a therapeutic target in breast cancer
Volume: 12 Issue: 12
Author(s): Angelos K. Koutras, Ioannis Starakis, Dionysia Lymperatou and Haralabos P. Kalofonos
Affiliation:
Keywords: Angiogenesis, bevacizumab, breast cancer, treatment.
Abstract: Current evidence indicates that angiogenesis plays an important role in the pathogenesis of several malignancies, including breast cancer. Bevacizumab is a monoclonal antibody that targets the vascular endothelial growth factor (VEGF). Recent clinical data have demonstrated that the addition of bevacizumab to first-line chemotherapy improves the progression-free survival of patients with advanced breast cancer. This review presents an update on the role of bevacizumab, as well as other anti-angiogenic agents in the management of patients with breast carcinoma.
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Cite this article as:
K. Koutras Angelos, Starakis Ioannis, Lymperatou Dionysia and P. Kalofonos Haralabos, Angiogenesis as a therapeutic target in breast cancer, Mini-Reviews in Medicinal Chemistry 2012; 12 (12) . https://dx.doi.org/10.2174/138955712802761988
DOI https://dx.doi.org/10.2174/138955712802761988 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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