Abstract
There is a critical need for the development of novel diagnostic and therapeutic strategies for pancreatic ductal adenocarcinoma (PDAC), a devastating disease known for its poor prognosis due to its late presentation and high aggressiveness. MicroRNAs (miRNAs) are a class of short non-coding RNAs that have been implicated in the gene regulation in normal cellular processes as well as cancer pathogenesis. Patterns of miRNA upregulation and downregulation have been found to be unique to specific cancers, including PDAC. MiRNA expression profiling may serve as a new strategy for the diagnosis and prognosis of PDAC cases. In addition, the role of miRNAs in important cellular processes such as cell development, survival, and proliferation may also be utilized for novel therapeutic approaches. This article presents current progress on the role of miRNAs as a biomarker and therapeutic target for PDAC.
Keywords: MicroRNA, pancreatic adenocarcinoma, prognosis, pathogenesis, oncogenic, ultrasound, formalin, metastasis, intratumoral, 2’-Omethoxethyl
Current Signal Transduction Therapy
Title:MicroRNAs and Pancreatic Cancer: Current Research and Future Outlooks
Volume: 7 Issue: 3
Author(s): Wei Li, Kei Satoh, Drake G. LeBrun and Min Li
Affiliation:
Keywords: MicroRNA, pancreatic adenocarcinoma, prognosis, pathogenesis, oncogenic, ultrasound, formalin, metastasis, intratumoral, 2’-Omethoxethyl
Abstract: There is a critical need for the development of novel diagnostic and therapeutic strategies for pancreatic ductal adenocarcinoma (PDAC), a devastating disease known for its poor prognosis due to its late presentation and high aggressiveness. MicroRNAs (miRNAs) are a class of short non-coding RNAs that have been implicated in the gene regulation in normal cellular processes as well as cancer pathogenesis. Patterns of miRNA upregulation and downregulation have been found to be unique to specific cancers, including PDAC. MiRNA expression profiling may serve as a new strategy for the diagnosis and prognosis of PDAC cases. In addition, the role of miRNAs in important cellular processes such as cell development, survival, and proliferation may also be utilized for novel therapeutic approaches. This article presents current progress on the role of miRNAs as a biomarker and therapeutic target for PDAC.
Export Options
About this article
Cite this article as:
Li Wei, Satoh Kei, G. LeBrun Drake and Li Min, MicroRNAs and Pancreatic Cancer: Current Research and Future Outlooks, Current Signal Transduction Therapy 2012; 7 (3) . https://dx.doi.org/10.2174/157436212802481529
DOI https://dx.doi.org/10.2174/157436212802481529 |
Print ISSN 1574-3624 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-389X |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Corneal Neovascularization: Molecular Events and Therapeutic Options
Recent Patents on Inflammation & Allergy Drug Discovery Chemical and Biological Profile of Dual Cdk1 and Cdk2 Inhibitors
Current Medicinal Chemistry - Anti-Cancer Agents Multiple Myeloma Bone Marrow Niche
Current Pharmaceutical Biotechnology Reactive Oxygen Species, Inflammation, and Lung Diseases
Current Pharmaceutical Design Testicular Germ Cell Tumors: A Paradigm for the Successful Treatment of Solid Tumor Stem Cells
Current Cancer Therapy Reviews Systemic DNA Damage Response and Metabolic Syndrome as a Premalignant State
Current Molecular Medicine Bridging Indigenous Knowledge and Scientific Evidence for Pharmacological Studies of <i>Phaleria macrocarpa</i>: A Systematic Review
The Natural Products Journal Antiproliferative Activity of microRNA-125a and its Molecular Targets
MicroRNA MicroRNAs: Modulators of Cell Identity, and their Applications in Tissue Engineering
MicroRNA Mouse Models of Primary Sjogren’s Syndrome
Current Pharmaceutical Design Gene Therapy Strategies in Prostate Cancer
Current Gene Therapy Epigenetic Therapies of Cancer
Current Cancer Therapy Reviews Clinical Significance of miR-1826 as a Novel Prognostic Biomarker in Colorectal Cancer
Anti-Cancer Agents in Medicinal Chemistry Human Platelet Acetylcholinesterase Inhibition by Cyclophosphamide: A Combined Experimental and Computational Approach
CNS & Neurological Disorders - Drug Targets Preferentially Expressed Antigen in Melanoma (PRAME) and the PRAME Family of Leucine-Rich Repeat Proteins
Current Cancer Drug Targets Update to: The Aryl Hydrocarbon Receptor in Anticancer Drug Discovery: Friend or Foe?
Medicinal Chemistry Reviews - Online (Discontinued) RAS Pathways in Prostate Cancer - Mediators of Hormone Resistance?
Current Cancer Drug Targets Contrast Functions of αA- and αB-Crystallins in Cancer Development
Current Molecular Medicine The Pathophysiological Role of PEDF in Bone Diseases
Current Molecular Medicine Molecular Targets in Gastrointestinal Stromal Tumors (GIST) Therapy
Current Cancer Drug Targets