Subtype-Selective Dopamine Receptor Radioligands for PET Imaging: Current Status and Recent Developments

A.      Banerjee; O.      Prante

doi:10.2174/092986712802002518

Abstract

This review presents a general overview of the subtype-selective dopamine receptor radioligands for in vivo imaging of dopamine receptor expression by positron emission tomography (PET). Besides the 11C- and 18F-labeled radioligands which are already in clinical use, a summary of subtype-selective radioligands which had been studied in vitro and in vivo is provided, which shines light onto the current status and recent developments in this field of radiopharmaceutical research.

Keywords: Dopamine, D2, D3, D4, dopamine receptor, selectivity, subtype-selectivity, positron emission tomography, PET, radioligand, PET ligand, radiopharmaceutical, F-18, C-11